BRAF(V600E)-induced, tumor intrinsic PD-L1 can regulate chemotherapy-induced apoptosis in human colon cancer cells and in tumor xenografts

Programmed death ligand 1 (PD-L1) is an immune checkpoint protein, however, emerging data suggest that tumor cell PD-L1 may regulate immune-independent and intrinsic cellular functions. We demonstrate regulation of PD-L1 by oncogenic BRAF(V600E) and investigated its ability to influence apoptotic su...

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Detalles Bibliográficos
Autores principales: Feng, Daofu, Qin, Bo, Pal, Krishnendu, Sun, Lei, Dutta, Shamit, Dong, Haidong, Liu, Xin, Mukhopadhyay, Debabrata, Huang, Shengbing, Sinicrope, Frank A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786951/
https://www.ncbi.nlm.nih.gov/pubmed/31406255
http://dx.doi.org/10.1038/s41388-019-0919-y

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