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Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients

Transdermal fentanyl is widely used to control pain in cancer patients. The high pharmacokinetic variability of fentanyl is assumed to be due to cytochrome P450 3A-mediated (CYP3A) N-dealkylation to norfentanyl in humans. However, recently published clinical studies question the importance of the de...

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Detalles Bibliográficos
Autores principales:	Geist, Marcus J. P., Ziesenitz, Victoria C., Bardenheuer, Hubert J., Burhenne, Juergen, Skopp, Gisela, Mikus, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786992/ https://www.ncbi.nlm.nih.gov/pubmed/31601999 http://dx.doi.org/10.1038/s41598-019-51279-6

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