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An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribu...

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Autores principales: Alves, Pedro Nascimento, Foulon, Chris, Karolis, Vyacheslav, Bzdok, Danilo, Margulies, Daniel S., Volle, Emmanuelle, Thiebaut de Schotten, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787009/
https://www.ncbi.nlm.nih.gov/pubmed/31633061
http://dx.doi.org/10.1038/s42003-019-0611-3
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author Alves, Pedro Nascimento
Foulon, Chris
Karolis, Vyacheslav
Bzdok, Danilo
Margulies, Daniel S.
Volle, Emmanuelle
Thiebaut de Schotten, Michel
author_facet Alves, Pedro Nascimento
Foulon, Chris
Karolis, Vyacheslav
Bzdok, Danilo
Margulies, Daniel S.
Volle, Emmanuelle
Thiebaut de Schotten, Michel
author_sort Alves, Pedro Nascimento
collection PubMed
description The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to the DMN may be underappreciated. Here, we propose a more comprehensive neuroanatomical model of the DMN including subcortical structures such as the basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity, which revealed that the thalamus and basal forebrain are of central importance for the functioning of the DMN. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brains and offers the potential for identifying a conserved homologue of the DMN in other mammalian species.
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spelling pubmed-67870092019-10-18 An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings Alves, Pedro Nascimento Foulon, Chris Karolis, Vyacheslav Bzdok, Danilo Margulies, Daniel S. Volle, Emmanuelle Thiebaut de Schotten, Michel Commun Biol Article The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to the DMN may be underappreciated. Here, we propose a more comprehensive neuroanatomical model of the DMN including subcortical structures such as the basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity, which revealed that the thalamus and basal forebrain are of central importance for the functioning of the DMN. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brains and offers the potential for identifying a conserved homologue of the DMN in other mammalian species. Nature Publishing Group UK 2019-10-10 /pmc/articles/PMC6787009/ /pubmed/31633061 http://dx.doi.org/10.1038/s42003-019-0611-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Alves, Pedro Nascimento
Foulon, Chris
Karolis, Vyacheslav
Bzdok, Danilo
Margulies, Daniel S.
Volle, Emmanuelle
Thiebaut de Schotten, Michel
An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
title An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
title_full An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
title_fullStr An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
title_full_unstemmed An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
title_short An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
title_sort improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787009/
https://www.ncbi.nlm.nih.gov/pubmed/31633061
http://dx.doi.org/10.1038/s42003-019-0611-3
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