DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G(2)-checkpoint in S-phase irradiated cells

We previously reported that cells exposed to low doses of ionizing radiation (IR) in the G(2)-phase of the cell cycle activate a checkpoint that is epistatically regulated by ATM and ATR operating as an integrated module. In this module, ATR interphases exclusively with the cell cycle to implement t...

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Detalles Bibliográficos
Autores principales: Mladenov, Emil, Fan, Xiaoxiang, Paul-Konietzko, Katja, Soni, Aashish, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787047/
https://www.ncbi.nlm.nih.gov/pubmed/31601897
http://dx.doi.org/10.1038/s41598-019-51071-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787047/
https://www.ncbi.nlm.nih.gov/pubmed/31601897
http://dx.doi.org/10.1038/s41598-019-51071-6

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