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Overview of natural hydrogels for regenerative medicine applications
Hydrogels from different materials can be used in biomedical field as an innovative approach in regenerative medicine. Depending on the origin source, hydrogels can be synthetized through chemical and physical methods. Hydrogel can be characterized through several physical parameters, such as size,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787111/ https://www.ncbi.nlm.nih.gov/pubmed/31599365 http://dx.doi.org/10.1007/s10856-019-6318-7 |
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author | Catoira, Marta Calvo Fusaro, Luca Di Francesco, Dalila Ramella, Martina Boccafoschi, Francesca |
author_facet | Catoira, Marta Calvo Fusaro, Luca Di Francesco, Dalila Ramella, Martina Boccafoschi, Francesca |
author_sort | Catoira, Marta Calvo |
collection | PubMed |
description | Hydrogels from different materials can be used in biomedical field as an innovative approach in regenerative medicine. Depending on the origin source, hydrogels can be synthetized through chemical and physical methods. Hydrogel can be characterized through several physical parameters, such as size, elastic modulus, swelling and degradation rate. Lately, research is focused on hydrogels derived from biologic materials. These hydrogels can be derived from protein polymers, such as collage, elastin, and polysaccharide polymers like glycosaminoglycans or alginate among others. Introduction of decellularized tissues into hydrogels synthesis displays several advantages compared to natural or synthetic based hydrogels. Preservation of natural molecules such as growth factors, glycans, bioactive cryptic peptides and natural proteins can promote cell growth, function, differentiation, angiogenesis, anti-angiogenesis, antimicrobial effects, and chemotactic effects. Versatility of hydrogels make possible multiple applications and combinations with several molecules on order to obtain the adequate characteristic for each scope. In this context, a lot of molecules such as cross link agents, drugs, grow factors or cells can be used. This review focuses on the recent progress of hydrogels synthesis and applications in order to classify the most recent and relevant matters in biomedical field. [Image: see text] |
format | Online Article Text |
id | pubmed-6787111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-67871112019-10-17 Overview of natural hydrogels for regenerative medicine applications Catoira, Marta Calvo Fusaro, Luca Di Francesco, Dalila Ramella, Martina Boccafoschi, Francesca J Mater Sci Mater Med Biomaterials Synthesis and Characterization Hydrogels from different materials can be used in biomedical field as an innovative approach in regenerative medicine. Depending on the origin source, hydrogels can be synthetized through chemical and physical methods. Hydrogel can be characterized through several physical parameters, such as size, elastic modulus, swelling and degradation rate. Lately, research is focused on hydrogels derived from biologic materials. These hydrogels can be derived from protein polymers, such as collage, elastin, and polysaccharide polymers like glycosaminoglycans or alginate among others. Introduction of decellularized tissues into hydrogels synthesis displays several advantages compared to natural or synthetic based hydrogels. Preservation of natural molecules such as growth factors, glycans, bioactive cryptic peptides and natural proteins can promote cell growth, function, differentiation, angiogenesis, anti-angiogenesis, antimicrobial effects, and chemotactic effects. Versatility of hydrogels make possible multiple applications and combinations with several molecules on order to obtain the adequate characteristic for each scope. In this context, a lot of molecules such as cross link agents, drugs, grow factors or cells can be used. This review focuses on the recent progress of hydrogels synthesis and applications in order to classify the most recent and relevant matters in biomedical field. [Image: see text] Springer US 2019-10-10 2019 /pmc/articles/PMC6787111/ /pubmed/31599365 http://dx.doi.org/10.1007/s10856-019-6318-7 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Biomaterials Synthesis and Characterization Catoira, Marta Calvo Fusaro, Luca Di Francesco, Dalila Ramella, Martina Boccafoschi, Francesca Overview of natural hydrogels for regenerative medicine applications |
title | Overview of natural hydrogels for regenerative medicine applications |
title_full | Overview of natural hydrogels for regenerative medicine applications |
title_fullStr | Overview of natural hydrogels for regenerative medicine applications |
title_full_unstemmed | Overview of natural hydrogels for regenerative medicine applications |
title_short | Overview of natural hydrogels for regenerative medicine applications |
title_sort | overview of natural hydrogels for regenerative medicine applications |
topic | Biomaterials Synthesis and Characterization |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787111/ https://www.ncbi.nlm.nih.gov/pubmed/31599365 http://dx.doi.org/10.1007/s10856-019-6318-7 |
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