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Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial

In vitro and animal studies have demonstrated that topical application and oral consumption of pomegranate reduces UVB-induced skin damage. We therefore investigated if oral pomegranate consumption will reduce photodamage from UVB irradiation and alter the composition of the skin microbiota in a ran...

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Autores principales: Henning, Susanne M., Yang, Jieping, Lee, Ru-Po, Huang, Jianjun, Hsu, Mark, Thames, Gail, Gilbuena, Irene, Long, Jianfeng, Xu, Yunhui, Park, Esther HaeIn, Tseng, Chi-Hong, Kim, Jenny, Heber, David, Li, Zhaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787198/
https://www.ncbi.nlm.nih.gov/pubmed/31601842
http://dx.doi.org/10.1038/s41598-019-50926-2
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author Henning, Susanne M.
Yang, Jieping
Lee, Ru-Po
Huang, Jianjun
Hsu, Mark
Thames, Gail
Gilbuena, Irene
Long, Jianfeng
Xu, Yunhui
Park, Esther HaeIn
Tseng, Chi-Hong
Kim, Jenny
Heber, David
Li, Zhaoping
author_facet Henning, Susanne M.
Yang, Jieping
Lee, Ru-Po
Huang, Jianjun
Hsu, Mark
Thames, Gail
Gilbuena, Irene
Long, Jianfeng
Xu, Yunhui
Park, Esther HaeIn
Tseng, Chi-Hong
Kim, Jenny
Heber, David
Li, Zhaoping
author_sort Henning, Susanne M.
collection PubMed
description In vitro and animal studies have demonstrated that topical application and oral consumption of pomegranate reduces UVB-induced skin damage. We therefore investigated if oral pomegranate consumption will reduce photodamage from UVB irradiation and alter the composition of the skin microbiota in a randomized controlled, parallel, three-arm, open label study. Seventy-four female participants (30–45 years) with Fitzpatrick skin type II-IV were randomly assigned (1:1:1) to 1000 mg of pomegranate extract (PomX), 8 oz of pomegranate juice (PomJ) or placebo for 12 weeks. Minimal erythema dose (MED) and melanin index were determined using a cutometer (mexameter probe). Skin microbiota was determined using 16S rRNA sequencing. The MED was significantly increased in the PomX and PomJ group compared to placebo. There was no significant difference on phylum, but on family and genus level bacterial composition of skin samples collected at baseline and after 12 week intervention showed significant differences between PomJ, PomX and placebo. Members of the Methylobacteriaceae family contain pigments absorbing UV irradiation and might contribute to UVB skin protection. However, we were not able to establish a direct correlation between increased MED and bacterial abundance. In summary daily oral pomegranate consumption may lead to enhanced protection from UV photodamage.
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spelling pubmed-67871982019-10-17 Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial Henning, Susanne M. Yang, Jieping Lee, Ru-Po Huang, Jianjun Hsu, Mark Thames, Gail Gilbuena, Irene Long, Jianfeng Xu, Yunhui Park, Esther HaeIn Tseng, Chi-Hong Kim, Jenny Heber, David Li, Zhaoping Sci Rep Article In vitro and animal studies have demonstrated that topical application and oral consumption of pomegranate reduces UVB-induced skin damage. We therefore investigated if oral pomegranate consumption will reduce photodamage from UVB irradiation and alter the composition of the skin microbiota in a randomized controlled, parallel, three-arm, open label study. Seventy-four female participants (30–45 years) with Fitzpatrick skin type II-IV were randomly assigned (1:1:1) to 1000 mg of pomegranate extract (PomX), 8 oz of pomegranate juice (PomJ) or placebo for 12 weeks. Minimal erythema dose (MED) and melanin index were determined using a cutometer (mexameter probe). Skin microbiota was determined using 16S rRNA sequencing. The MED was significantly increased in the PomX and PomJ group compared to placebo. There was no significant difference on phylum, but on family and genus level bacterial composition of skin samples collected at baseline and after 12 week intervention showed significant differences between PomJ, PomX and placebo. Members of the Methylobacteriaceae family contain pigments absorbing UV irradiation and might contribute to UVB skin protection. However, we were not able to establish a direct correlation between increased MED and bacterial abundance. In summary daily oral pomegranate consumption may lead to enhanced protection from UV photodamage. Nature Publishing Group UK 2019-10-10 /pmc/articles/PMC6787198/ /pubmed/31601842 http://dx.doi.org/10.1038/s41598-019-50926-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Henning, Susanne M.
Yang, Jieping
Lee, Ru-Po
Huang, Jianjun
Hsu, Mark
Thames, Gail
Gilbuena, Irene
Long, Jianfeng
Xu, Yunhui
Park, Esther HaeIn
Tseng, Chi-Hong
Kim, Jenny
Heber, David
Li, Zhaoping
Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
title Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
title_full Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
title_fullStr Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
title_full_unstemmed Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
title_short Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial
title_sort pomegranate juice and extract consumption increases the resistance to uvb-induced erythema and changes the skin microbiome in healthy women: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787198/
https://www.ncbi.nlm.nih.gov/pubmed/31601842
http://dx.doi.org/10.1038/s41598-019-50926-2
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