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Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics
Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectiou...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787278/ https://www.ncbi.nlm.nih.gov/pubmed/31636560 http://dx.doi.org/10.3389/fphar.2019.01121 |
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author | Labruère, Raphaël Sona, A. J. Turos, Edward |
author_facet | Labruère, Raphaël Sona, A. J. Turos, Edward |
author_sort | Labruère, Raphaël |
collection | PubMed |
description | Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectious diseases. Among these are ones due to bacterial infections, which can cause serious illnesses leading to death. The onset of multi-drug-resistant (MDR) infections such as those caused by the human pathogen Staphylococcus aureus has created a dearth of problems such as surgical complications, persistent infections, and lack of available treatments. In this article, we set out to review the primary literature on the design and development of new nanoparticle materials for the potential treatment of S. aureus infections, and areas that could be further expanded upon to make nanoparticle antibiotics a mainstay in clinical settings. |
format | Online Article Text |
id | pubmed-6787278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67872782019-10-21 Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics Labruère, Raphaël Sona, A. J. Turos, Edward Front Pharmacol Pharmacology Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectious diseases. Among these are ones due to bacterial infections, which can cause serious illnesses leading to death. The onset of multi-drug-resistant (MDR) infections such as those caused by the human pathogen Staphylococcus aureus has created a dearth of problems such as surgical complications, persistent infections, and lack of available treatments. In this article, we set out to review the primary literature on the design and development of new nanoparticle materials for the potential treatment of S. aureus infections, and areas that could be further expanded upon to make nanoparticle antibiotics a mainstay in clinical settings. Frontiers Media S.A. 2019-10-04 /pmc/articles/PMC6787278/ /pubmed/31636560 http://dx.doi.org/10.3389/fphar.2019.01121 Text en Copyright © 2019 Labruère, Sona and Turos http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Labruère, Raphaël Sona, A. J. Turos, Edward Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics |
title | Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics |
title_full | Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics |
title_fullStr | Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics |
title_full_unstemmed | Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics |
title_short | Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics |
title_sort | anti–methicillin-resistant staphylococcus aureus nanoantibiotics |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787278/ https://www.ncbi.nlm.nih.gov/pubmed/31636560 http://dx.doi.org/10.3389/fphar.2019.01121 |
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