Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome

The NPHS2 gene, encoding the slit diaphragm protein podocin, accounts for genetic and sporadic forms of nephrotic syndrome (NS). Patients with NS often present symptoms of volume retention, such as oedema formation or hypertension. The primary dysregulation in sodium handling involves an inappropria...

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Detalles Bibliográficos
Autores principales: Larionov, Alexey, Dahlke, Eileen, Kunke, Madlen, Zanon Rodriguez, Luis, Schiessl, Ina M., Magnin, Jean‐Luc, Kern, Ursula, Alli, Abdel A., Mollet, Geraldine, Schilling, Oliver, Castrop, Hayo, Theilig, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787568/
https://www.ncbi.nlm.nih.gov/pubmed/31368174
http://dx.doi.org/10.1111/jcmm.14387

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