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The Mediterranean Diet and Breast Cancer: A Personalised Approach

There have been many original and review articles summarizing the impact of nutrition and diet on breast cancer risk. However, very few consider the implication of genetic background and the effect of personalised nutrition on the risk and prognosis of breast cancer. A literature search was performe...

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Detalles Bibliográficos
Autores principales: Shaikh, Amani Al, Braakhuis, Andrea J., Bishop, Karen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787593/
https://www.ncbi.nlm.nih.gov/pubmed/31505792
http://dx.doi.org/10.3390/healthcare7030104
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author Shaikh, Amani Al
Braakhuis, Andrea J.
Bishop, Karen S.
author_facet Shaikh, Amani Al
Braakhuis, Andrea J.
Bishop, Karen S.
author_sort Shaikh, Amani Al
collection PubMed
description There have been many original and review articles summarizing the impact of nutrition and diet on breast cancer risk. However, very few consider the implication of genetic background and the effect of personalised nutrition on the risk and prognosis of breast cancer. A literature search was performed using the following databases: MEDLINE (Ovid), PubMed, Scopus and EMBASE (Ovid). The ensuing search terms were selected: genomics, nutrigenomics, breast cancer, breast neoplasms, cancer, nutrigenetics, diet–gene interaction, and Mediterranean, nutrition, polyphenols and diet. In this review, we discuss the Mediterranean-style diet and associated nutrients, evidence of benefit, impact on gene expression and evidence of interactions with genotype and how this interaction can modify breast cancer risk and progression. In addition, the impact of nutrients commonly associated with a Mediterranean-style diet, on breast cancer treatment, and synergistic effects are mentioned when modified by genotype. Some evidence exists around the benefit of a gene-based personalised diet based on a Mediterranean-style dietary pattern, but further evidence in the form of clinical trials is required before such an approach can be comprehensively implemented.
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spelling pubmed-67875932019-10-16 The Mediterranean Diet and Breast Cancer: A Personalised Approach Shaikh, Amani Al Braakhuis, Andrea J. Bishop, Karen S. Healthcare (Basel) Review There have been many original and review articles summarizing the impact of nutrition and diet on breast cancer risk. However, very few consider the implication of genetic background and the effect of personalised nutrition on the risk and prognosis of breast cancer. A literature search was performed using the following databases: MEDLINE (Ovid), PubMed, Scopus and EMBASE (Ovid). The ensuing search terms were selected: genomics, nutrigenomics, breast cancer, breast neoplasms, cancer, nutrigenetics, diet–gene interaction, and Mediterranean, nutrition, polyphenols and diet. In this review, we discuss the Mediterranean-style diet and associated nutrients, evidence of benefit, impact on gene expression and evidence of interactions with genotype and how this interaction can modify breast cancer risk and progression. In addition, the impact of nutrients commonly associated with a Mediterranean-style diet, on breast cancer treatment, and synergistic effects are mentioned when modified by genotype. Some evidence exists around the benefit of a gene-based personalised diet based on a Mediterranean-style dietary pattern, but further evidence in the form of clinical trials is required before such an approach can be comprehensively implemented. MDPI 2019-09-09 /pmc/articles/PMC6787593/ /pubmed/31505792 http://dx.doi.org/10.3390/healthcare7030104 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shaikh, Amani Al
Braakhuis, Andrea J.
Bishop, Karen S.
The Mediterranean Diet and Breast Cancer: A Personalised Approach
title The Mediterranean Diet and Breast Cancer: A Personalised Approach
title_full The Mediterranean Diet and Breast Cancer: A Personalised Approach
title_fullStr The Mediterranean Diet and Breast Cancer: A Personalised Approach
title_full_unstemmed The Mediterranean Diet and Breast Cancer: A Personalised Approach
title_short The Mediterranean Diet and Breast Cancer: A Personalised Approach
title_sort mediterranean diet and breast cancer: a personalised approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787593/
https://www.ncbi.nlm.nih.gov/pubmed/31505792
http://dx.doi.org/10.3390/healthcare7030104
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