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The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes

The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1 diabetes (T1D) in comparison to the control group and in relation to markers of diabetes metabolic control. The study group consisted of 111 patients with an average of 6-years of T1D duration. The...

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Autores principales: Kołodziej, Magdalena, Waszczykowska, Arleta, Korzeniewska-Dyl, Irmina, Pyziak-Skupien, Aleksandra, Walczak, Konrad, Moczulski, Dariusz, Jurowski, Piotr, Młynarski, Wojciech, Szadkowska, Agnieszka, Zmysłowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787605/
https://www.ncbi.nlm.nih.gov/pubmed/31454902
http://dx.doi.org/10.3390/diagnostics9030105
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author Kołodziej, Magdalena
Waszczykowska, Arleta
Korzeniewska-Dyl, Irmina
Pyziak-Skupien, Aleksandra
Walczak, Konrad
Moczulski, Dariusz
Jurowski, Piotr
Młynarski, Wojciech
Szadkowska, Agnieszka
Zmysłowska, Agnieszka
author_facet Kołodziej, Magdalena
Waszczykowska, Arleta
Korzeniewska-Dyl, Irmina
Pyziak-Skupien, Aleksandra
Walczak, Konrad
Moczulski, Dariusz
Jurowski, Piotr
Młynarski, Wojciech
Szadkowska, Agnieszka
Zmysłowska, Agnieszka
author_sort Kołodziej, Magdalena
collection PubMed
description The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1 diabetes (T1D) in comparison to the control group and in relation to markers of diabetes metabolic control. The study group consisted of 111 patients with an average of 6-years of T1D duration. The control group included 36 gender- and age-matched individuals. In all patients optical coherence tomography (OCT) study was performed using HD-OCT Cirrus 5000 with evaluation of optic nerve head (ONH) parameters, thickness of retinal nerve fiber layer (RNFL) with its quadrants, macular full-thickness parameters, ganglion cells with inner plexus layer (GCIPL) and choroidal thickness (CT). Lower disc area value was observed in the study group as compared to controls (p = 0.0215). Negative correlations were found both between age at examination and rim area (R = −0.28, p = 0.0007) and between superior RNFL thickness and duration of diabetes (R = −0.20, p = 0.0336). Positive correlation between center thickness and SD for average glycemia (R = 0.30, p = 0.0071) was noted. Temporal CT correlated positively with age at examination (R = 0.21, p = 0.0127). The selected parameters the HD-OCT study may in the future serve as potential markers of preclinical phase of DR in patients with T1D.
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spelling pubmed-67876052019-10-16 The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes Kołodziej, Magdalena Waszczykowska, Arleta Korzeniewska-Dyl, Irmina Pyziak-Skupien, Aleksandra Walczak, Konrad Moczulski, Dariusz Jurowski, Piotr Młynarski, Wojciech Szadkowska, Agnieszka Zmysłowska, Agnieszka Diagnostics (Basel) Article The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1 diabetes (T1D) in comparison to the control group and in relation to markers of diabetes metabolic control. The study group consisted of 111 patients with an average of 6-years of T1D duration. The control group included 36 gender- and age-matched individuals. In all patients optical coherence tomography (OCT) study was performed using HD-OCT Cirrus 5000 with evaluation of optic nerve head (ONH) parameters, thickness of retinal nerve fiber layer (RNFL) with its quadrants, macular full-thickness parameters, ganglion cells with inner plexus layer (GCIPL) and choroidal thickness (CT). Lower disc area value was observed in the study group as compared to controls (p = 0.0215). Negative correlations were found both between age at examination and rim area (R = −0.28, p = 0.0007) and between superior RNFL thickness and duration of diabetes (R = −0.20, p = 0.0336). Positive correlation between center thickness and SD for average glycemia (R = 0.30, p = 0.0071) was noted. Temporal CT correlated positively with age at examination (R = 0.21, p = 0.0127). The selected parameters the HD-OCT study may in the future serve as potential markers of preclinical phase of DR in patients with T1D. MDPI 2019-08-26 /pmc/articles/PMC6787605/ /pubmed/31454902 http://dx.doi.org/10.3390/diagnostics9030105 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kołodziej, Magdalena
Waszczykowska, Arleta
Korzeniewska-Dyl, Irmina
Pyziak-Skupien, Aleksandra
Walczak, Konrad
Moczulski, Dariusz
Jurowski, Piotr
Młynarski, Wojciech
Szadkowska, Agnieszka
Zmysłowska, Agnieszka
The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes
title The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes
title_full The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes
title_fullStr The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes
title_full_unstemmed The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes
title_short The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes
title_sort hd-oct study may be useful in searching for markers of preclinical stage of diabetic retinopathy in patients with type 1 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787605/
https://www.ncbi.nlm.nih.gov/pubmed/31454902
http://dx.doi.org/10.3390/diagnostics9030105
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