Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro

The aim of the study was to evaluate the influence of hypoxia on galactomannan and (1,3)-β-d-glucan release of clinically relevant Aspergilli in vitro. Hypoxia decreased biomass and consequently led to lower biomarker release. However, when normalized to biomass, hypoxia led to increased levels of b...

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Detalles Bibliográficos
Autores principales: Maurer, Elisabeth, Aigner, Maria, Lass-Flörl, Cornelia, Binder, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787614/
https://www.ncbi.nlm.nih.gov/pubmed/31336719
http://dx.doi.org/10.3390/jof5030061
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author Maurer, Elisabeth
Aigner, Maria
Lass-Flörl, Cornelia
Binder, Ulrike
author_facet Maurer, Elisabeth
Aigner, Maria
Lass-Flörl, Cornelia
Binder, Ulrike
author_sort Maurer, Elisabeth
collection PubMed
description The aim of the study was to evaluate the influence of hypoxia on galactomannan and (1,3)-β-d-glucan release of clinically relevant Aspergilli in vitro. Hypoxia decreased biomass and consequently led to lower biomarker release. However, when normalized to biomass, hypoxia led to increased levels of biomarkers at early growth stages (24 h). Antifungals (amphotericin B and voriconazole) decreased the galactomannan amount of A. fumigatus, even more prominently in hypoxia.
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spelling pubmed-67876142019-10-16 Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro Maurer, Elisabeth Aigner, Maria Lass-Flörl, Cornelia Binder, Ulrike J Fungi (Basel) Communication The aim of the study was to evaluate the influence of hypoxia on galactomannan and (1,3)-β-d-glucan release of clinically relevant Aspergilli in vitro. Hypoxia decreased biomass and consequently led to lower biomarker release. However, when normalized to biomass, hypoxia led to increased levels of biomarkers at early growth stages (24 h). Antifungals (amphotericin B and voriconazole) decreased the galactomannan amount of A. fumigatus, even more prominently in hypoxia. MDPI 2019-07-11 /pmc/articles/PMC6787614/ /pubmed/31336719 http://dx.doi.org/10.3390/jof5030061 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Maurer, Elisabeth
Aigner, Maria
Lass-Flörl, Cornelia
Binder, Ulrike
Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro
title Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro
title_full Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro
title_fullStr Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro
title_full_unstemmed Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro
title_short Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro
title_sort hypoxia decreases diagnostic biomarkers for aspergillosis in vitro
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787614/
https://www.ncbi.nlm.nih.gov/pubmed/31336719
http://dx.doi.org/10.3390/jof5030061
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AT lassflorlcornelia hypoxiadecreasesdiagnosticbiomarkersforaspergillosisinvitro
AT binderulrike hypoxiadecreasesdiagnosticbiomarkersforaspergillosisinvitro

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