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Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ

Liver fibrosis staging is of great clinical importance because it is used to assess the severity of the underlying chronic liver disease. Among various imaging-based methods, apparent diffusion coefficient (ADC) measurement using diffusion-weighted imaging (DWI) has the potential to be used as an im...

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Autores principales: Shin, Min Ki, Song, Ji Soo, Hwang, Seung Bae, Hwang, Hong Pil, Kim, Young Jun, Moon, Woo Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787628/
https://www.ncbi.nlm.nih.gov/pubmed/31466404
http://dx.doi.org/10.3390/diagnostics9030107
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author Shin, Min Ki
Song, Ji Soo
Hwang, Seung Bae
Hwang, Hong Pil
Kim, Young Jun
Moon, Woo Sung
author_facet Shin, Min Ki
Song, Ji Soo
Hwang, Seung Bae
Hwang, Hong Pil
Kim, Young Jun
Moon, Woo Sung
author_sort Shin, Min Ki
collection PubMed
description Liver fibrosis staging is of great clinical importance because it is used to assess the severity of the underlying chronic liver disease. Among various imaging-based methods, apparent diffusion coefficient (ADC) measurement using diffusion-weighted imaging (DWI) has the potential to be used as an imaging biomarker for liver fibrosis assessment. In this study, we investigated the usefulness of liver ADC normalization using the spleen as a reference organ in liver fibrosis staging with 66 patients who underwent liver magnetic resonance imaging (MRI), transient elastography (TE), and surgical resection of a hepatic mass. ADC values of the liver (ADC(liver)) and spleen were analyzed, and the spleen was used for ADC(liver) normalization (nADC(liver)). ADC(liver) showed a weak negative correlation with TE (r = −0.246; p = 0.047) and fibrosis stage (r = −0.269; p = 0.029), while n ADC(liver) showed a moderate negative correlation with TE (r = −0.504; p < 0.001) and fibrosis stage (r = −0.579; p < 0.001). AUC values for nADC(liver) (0.777–0.875) were higher than those for ADC(liver) for each stage of fibrosis (0.596–0.713, p = 0.037–0.157). AUC values for TE (0.726–0.884) and nADC(liver) were not statistically different. In conclusion, normalized liver ADC can be useful in diagnosing liver fibrosis stage in patients with variable DWI acquisitions.
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spelling pubmed-67876282019-10-16 Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ Shin, Min Ki Song, Ji Soo Hwang, Seung Bae Hwang, Hong Pil Kim, Young Jun Moon, Woo Sung Diagnostics (Basel) Article Liver fibrosis staging is of great clinical importance because it is used to assess the severity of the underlying chronic liver disease. Among various imaging-based methods, apparent diffusion coefficient (ADC) measurement using diffusion-weighted imaging (DWI) has the potential to be used as an imaging biomarker for liver fibrosis assessment. In this study, we investigated the usefulness of liver ADC normalization using the spleen as a reference organ in liver fibrosis staging with 66 patients who underwent liver magnetic resonance imaging (MRI), transient elastography (TE), and surgical resection of a hepatic mass. ADC values of the liver (ADC(liver)) and spleen were analyzed, and the spleen was used for ADC(liver) normalization (nADC(liver)). ADC(liver) showed a weak negative correlation with TE (r = −0.246; p = 0.047) and fibrosis stage (r = −0.269; p = 0.029), while n ADC(liver) showed a moderate negative correlation with TE (r = −0.504; p < 0.001) and fibrosis stage (r = −0.579; p < 0.001). AUC values for nADC(liver) (0.777–0.875) were higher than those for ADC(liver) for each stage of fibrosis (0.596–0.713, p = 0.037–0.157). AUC values for TE (0.726–0.884) and nADC(liver) were not statistically different. In conclusion, normalized liver ADC can be useful in diagnosing liver fibrosis stage in patients with variable DWI acquisitions. MDPI 2019-08-28 /pmc/articles/PMC6787628/ /pubmed/31466404 http://dx.doi.org/10.3390/diagnostics9030107 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shin, Min Ki
Song, Ji Soo
Hwang, Seung Bae
Hwang, Hong Pil
Kim, Young Jun
Moon, Woo Sung
Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ
title Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ
title_full Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ
title_fullStr Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ
title_full_unstemmed Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ
title_short Liver Fibrosis Assessment with Diffusion-Weighted Imaging: Value of Liver Apparent Diffusion Coefficient Normalization Using the Spleen as a Reference Organ
title_sort liver fibrosis assessment with diffusion-weighted imaging: value of liver apparent diffusion coefficient normalization using the spleen as a reference organ
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787628/
https://www.ncbi.nlm.nih.gov/pubmed/31466404
http://dx.doi.org/10.3390/diagnostics9030107
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