Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient

Our rechallenge of cobimetinib in an Erdheim‐Chester Disease (ECD) patient for the rare adverse effect, “dropped head syndrome,” with a previously unexplored cobimetinib regimen was successful. Similar to other experiences with targeted agents in ECD, dosing of cobimetinib may vary to mitigate toxic...

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Autores principales: King, Amber C., Diamond, Eli L., Orozco, Jennifer S., Morse, Hannah R., Ouyang, Linda L., Schöder, Heiko, Rampal, Raajit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787838/
https://www.ncbi.nlm.nih.gov/pubmed/31624624
http://dx.doi.org/10.1002/ccr3.2297
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author King, Amber C.
Diamond, Eli L.
Orozco, Jennifer S.
Morse, Hannah R.
Ouyang, Linda L.
Schöder, Heiko
Rampal, Raajit K.
author_facet King, Amber C.
Diamond, Eli L.
Orozco, Jennifer S.
Morse, Hannah R.
Ouyang, Linda L.
Schöder, Heiko
Rampal, Raajit K.
author_sort King, Amber C.
collection PubMed
description Our rechallenge of cobimetinib in an Erdheim‐Chester Disease (ECD) patient for the rare adverse effect, “dropped head syndrome,” with a previously unexplored cobimetinib regimen was successful. Similar to other experiences with targeted agents in ECD, dosing of cobimetinib may vary to mitigate toxicity without impairing efficacy.
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spelling pubmed-67878382019-10-17 Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient King, Amber C. Diamond, Eli L. Orozco, Jennifer S. Morse, Hannah R. Ouyang, Linda L. Schöder, Heiko Rampal, Raajit K. Clin Case Rep Case Reports Our rechallenge of cobimetinib in an Erdheim‐Chester Disease (ECD) patient for the rare adverse effect, “dropped head syndrome,” with a previously unexplored cobimetinib regimen was successful. Similar to other experiences with targeted agents in ECD, dosing of cobimetinib may vary to mitigate toxicity without impairing efficacy. John Wiley and Sons Inc. 2019-09-10 /pmc/articles/PMC6787838/ /pubmed/31624624 http://dx.doi.org/10.1002/ccr3.2297 Text en © 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
King, Amber C.
Diamond, Eli L.
Orozco, Jennifer S.
Morse, Hannah R.
Ouyang, Linda L.
Schöder, Heiko
Rampal, Raajit K.
Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
title Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
title_full Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
title_fullStr Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
title_full_unstemmed Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
title_short Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
title_sort cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an erdheim‐chester patient
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787838/
https://www.ncbi.nlm.nih.gov/pubmed/31624624
http://dx.doi.org/10.1002/ccr3.2297
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