Cargando…
Feline coronavirus-associated myocarditis in a domestic longhair cat
CASE SUMMARY: A 9-month-old entire male domestic longhair indoor cat presented with a 3-week history of fluctuating fever, weight loss and small intestine diarrhoea, which was unresponsive to antibiotics and supportive treatment. Abdominal ultrasound revealed severe jejunal and ileocolic junction in...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787879/ https://www.ncbi.nlm.nih.gov/pubmed/31636915 http://dx.doi.org/10.1177/2055116919879256 |
_version_ | 1783458376843264000 |
---|---|
author | Ernandes, Maria A Cantoni, Anna M Armando, Federico Corradi, Attilio Ressel, Lorenzo Tamborini, Alice |
author_facet | Ernandes, Maria A Cantoni, Anna M Armando, Federico Corradi, Attilio Ressel, Lorenzo Tamborini, Alice |
author_sort | Ernandes, Maria A |
collection | PubMed |
description | CASE SUMMARY: A 9-month-old entire male domestic longhair indoor cat presented with a 3-week history of fluctuating fever, weight loss and small intestine diarrhoea, which was unresponsive to antibiotics and supportive treatment. Abdominal ultrasound revealed severe jejunal and ileocolic junction intestinal wall thickening with loss of layering. An enterectomy was performed and histopathology revealed severe pyogranulomatous enteritis with vasculitits, compatible with the diagnosis of feline infectious peritonitis (FIP). Four days after surgery, the cat re-presented with anorexia and acute onset of expiratory dyspnoea. Echocardiography showed left ventricular hypertrophy and bilateral atrial enlargement. Congestive heart failure caused by hypertrophic cardiomyopathy was suspected and treatment with furosemide was started, which led to amelioration of the clinical signs. The following day, four-limb ataxia, hypermetria and bilateral uveitis were evident. Given the persistent anorexia and worsening of the clinical signs, the cat was humanely euthanized and a post-mortem examination was performed. Necropsy revealed multifocal pyogranulomatous lesions involving multiple organs (adrenal glands, kidneys, lungs, brain, myocardium, lymph nodes, liver), compatible with the diagnosis of FIP. Immunohistochemistry performed on the myocardium revealed feline coronavirus-positive macrophages associated with pyogranulomatous lesions, justifying a diagnosis of feline coronavirus-associated myocarditis. RELEVANCE AND NOVEL INFORMATION: To the authors’ knowledge, the case described here represents the first published report of feline coronavirus-associated myocarditis. This should be considered as a possible differential diagnosis in cats presenting with cardiac-related signs and other clinical signs compatible with FIP. |
format | Online Article Text |
id | pubmed-6787879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67878792019-10-21 Feline coronavirus-associated myocarditis in a domestic longhair cat Ernandes, Maria A Cantoni, Anna M Armando, Federico Corradi, Attilio Ressel, Lorenzo Tamborini, Alice JFMS Open Rep Case Report CASE SUMMARY: A 9-month-old entire male domestic longhair indoor cat presented with a 3-week history of fluctuating fever, weight loss and small intestine diarrhoea, which was unresponsive to antibiotics and supportive treatment. Abdominal ultrasound revealed severe jejunal and ileocolic junction intestinal wall thickening with loss of layering. An enterectomy was performed and histopathology revealed severe pyogranulomatous enteritis with vasculitits, compatible with the diagnosis of feline infectious peritonitis (FIP). Four days after surgery, the cat re-presented with anorexia and acute onset of expiratory dyspnoea. Echocardiography showed left ventricular hypertrophy and bilateral atrial enlargement. Congestive heart failure caused by hypertrophic cardiomyopathy was suspected and treatment with furosemide was started, which led to amelioration of the clinical signs. The following day, four-limb ataxia, hypermetria and bilateral uveitis were evident. Given the persistent anorexia and worsening of the clinical signs, the cat was humanely euthanized and a post-mortem examination was performed. Necropsy revealed multifocal pyogranulomatous lesions involving multiple organs (adrenal glands, kidneys, lungs, brain, myocardium, lymph nodes, liver), compatible with the diagnosis of FIP. Immunohistochemistry performed on the myocardium revealed feline coronavirus-positive macrophages associated with pyogranulomatous lesions, justifying a diagnosis of feline coronavirus-associated myocarditis. RELEVANCE AND NOVEL INFORMATION: To the authors’ knowledge, the case described here represents the first published report of feline coronavirus-associated myocarditis. This should be considered as a possible differential diagnosis in cats presenting with cardiac-related signs and other clinical signs compatible with FIP. SAGE Publications 2019-10-10 /pmc/articles/PMC6787879/ /pubmed/31636915 http://dx.doi.org/10.1177/2055116919879256 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Ernandes, Maria A Cantoni, Anna M Armando, Federico Corradi, Attilio Ressel, Lorenzo Tamborini, Alice Feline coronavirus-associated myocarditis in a domestic longhair cat |
title | Feline coronavirus-associated myocarditis in a domestic longhair
cat |
title_full | Feline coronavirus-associated myocarditis in a domestic longhair
cat |
title_fullStr | Feline coronavirus-associated myocarditis in a domestic longhair
cat |
title_full_unstemmed | Feline coronavirus-associated myocarditis in a domestic longhair
cat |
title_short | Feline coronavirus-associated myocarditis in a domestic longhair
cat |
title_sort | feline coronavirus-associated myocarditis in a domestic longhair
cat |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787879/ https://www.ncbi.nlm.nih.gov/pubmed/31636915 http://dx.doi.org/10.1177/2055116919879256 |
work_keys_str_mv | AT ernandesmariaa felinecoronavirusassociatedmyocarditisinadomesticlonghaircat AT cantoniannam felinecoronavirusassociatedmyocarditisinadomesticlonghaircat AT armandofederico felinecoronavirusassociatedmyocarditisinadomesticlonghaircat AT corradiattilio felinecoronavirusassociatedmyocarditisinadomesticlonghaircat AT ressellorenzo felinecoronavirusassociatedmyocarditisinadomesticlonghaircat AT tamborinialice felinecoronavirusassociatedmyocarditisinadomesticlonghaircat |