Cargando…

Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8(+) T cells

BACKGROUND: Several mechanisms are present in the tumor microenvironment (TME) to impair cytotoxic T cell responses potentially able to control tumor growth. Among these, the accumulation of adenosine (Ado) contributes to tumor progression and represents a promising immunotherapeutic target. Ado has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mastelic-Gavillet, Beatris, Navarro Rodrigo, Blanca, Décombaz, Laure, Wang, Haiping, Ercolano, Giuseppe, Ahmed, Rita, Lozano, Leyder Elena, Ianaro, Angela, Derré, Laurent, Valerio, Massimo, Tawadros, Thomas, Jichlinski, Patrice, Nguyen-Ngoc, Tu, Speiser, Daniel E., Verdeil, Grégory, Gestermann, Nicolas, Dormond, Olivier, Kandalaft, Lana, Coukos, George, Jandus, Camilla, Ménétrier-Caux, Christine, Caux, Christophe, Ho, Ping-Chih, Romero, Pedro, Harari, Alexandre, Vigano, Selena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788118/ https://www.ncbi.nlm.nih.gov/pubmed/31601268 http://dx.doi.org/10.1186/s40425-019-0719-5

Ejemplares similares

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
por: Vigano, Selena, et al.
Publicado: (2019)

Longitudinal analysis of DC subsets in patients with ovarian cancer: Implications for immunotherapy
por: Mastelic-Gavillet, Beatris, et al.
Publicado: (2023)

Phenotype and Reactivity of Lymphocytes Expanded from Benign Prostate Hyperplasic Tissues and Prostate Cancer
por: Ahmed, Ritaparna, et al.
Publicado: (2023)

CD73 expression and clinical significance in human metastatic melanoma
por: Monteiro, Inês, et al.
Publicado: (2018)

Personalized Dendritic Cell Vaccines—Recent Breakthroughs and Encouraging Clinical Results
por: Mastelic-Gavillet, Beatris, et al.
Publicado: (2019)

MDR1 in immunity: friend or foe?
por: Bossennec, Marion, et al.
Publicado: (2018)

Lymphopenia in Cancer Patients and its Effects on Response to Immunotherapy: an opportunity for combination with Cytokines?
por: Ménétrier-Caux, Christine, et al.
Publicado: (2019)

Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
por: Ménétrier-Caux, Christine, et al.
Publicado: (2012)

ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells
por: Faget, Julien, et al.
Publicado: (2013)

Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients
por: Sisirak, Vanja, et al.
Publicado: (2013)

Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them?
por: Cinier, Justine, et al.
Publicado: (2021)

Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure
por: Vigano, Selena, et al.
Publicado: (2020)

A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system
por: Burlion, Aude, et al.
Publicado: (2019)

Renal cell carcinoma induces interleukin 10 and prostaglandin E(2) production by monocytes
por: Ménétrier-Caux, C, et al.
Publicado: (1999)

Autoantibodies to endostatin in patients with breast cancer: correlation to endostatin levels and clinical outcome
por: Bachelot, T, et al.
Publicado: (2006)

A TLR7/8 Agonist-Including DOEPC-Based Cationic Liposome Formulation Mediates Its Adjuvanticity Through the Sustained Recruitment of Highly Activated Monocytes in a Type I IFN-Independent but NF-κB-Dependent Manner
por: Auderset, Floriane, et al.
Publicado: (2020)

Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients
por: Bachelot, T, et al.
Publicado: (2003)

Effect of acute aerobic exercise before immunotherapy and chemotherapy infusion in patients with metastatic non-small-cell lung cancer: protocol for the ERICA feasibility trial
por: Gouez, Manon, et al.
Publicado: (2022)

Methotrexate Restores CD73 Expression on Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis Patients and May Contribute to Its Anti-Inflammatory Effect through Ado Production
por: Bossennec, Marion, et al.
Publicado: (2019)

Optimized combinatorial pMHC class II multimer labeling for precision immune monitoring of tumor-specific CD4 T cells in patients
por: Rockinger, Georg Alexander, et al.
Publicado: (2020)

LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures
por: Gestermann, Nicolas, et al.
Publicado: (2020)

Immune cell dysfunctions in breast cancer patients detected through whole blood multi-parametric flow cytometry assay
por: Verronèse, E., et al.
Publicado: (2015)

Healthy and Patient Type 2 Innate Lymphoid Cells are Differently Affected by in vitro Culture Conditions
por: Falquet, Maryline, et al.
Publicado: (2021)

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds
por: Ercolano, Giuseppe, et al.
Publicado: (2019)

The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion
por: De Cicco, Paola, et al.
Publicado: (2020)

Prognostic value of the expression of C-Chemokine Receptor 6 and 7 and their ligands in non-metastatic breast cancer
por: Cassier, Philippe A, et al.
Publicado: (2011)

Clinical translation section: accelerating the pace from bench to bedside
por: Kandalaft, Lana E, et al.
Publicado: (2011)

Disequilibrium of BMP2 Levels in the Breast Stem Cell Niche Launches Epithelial Transformation by Overamplifying BMPR1B Cell Response
por: Chapellier, Marion, et al.
Publicado: (2015)

Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma
por: Dufresne, A., et al.
Publicado: (2020)

MDR1-EXPRESSING CD4(+) T CELLS WITH TH1.17 FEATURES RESIST TO NEOADJUVANT CHEMOTHERAPY AND ARE ASSOCIATED WITH BREAST CANCER CLINICAL RESPONSE
por: Di Roio, Anthony, et al.
Publicado: (2023)

Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses
por: Mastelic-Gavillet, Beatris, et al.
Publicado: (2019)

Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria
por: Pérez-Mazliah, Damián, et al.
Publicado: (2015)

Double Positive CD4(+)CD8(+) T Cells Are Enriched in Urological Cancers and Favor T Helper-2 Polarization
por: Bohner, Perrine, et al.
Publicado: (2019)

Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition
por: De Cicco, Paola, et al.
Publicado: (2022)

CD163(+) tumor‐associated macrophage accumulation in breast cancer patients reflects both local differentiation signals and systemic skewing of monocytes
por: Ramos, Rodrigo Nalio, et al.
Publicado: (2020)

Pembrolizumab in Lymphopenic Metastatic Breast Cancer Patients Treated with Metronomic Cyclophosphamide: A Clinical and Translational Prospective Study
por: Mery, Benoîte, et al.
Publicado: (2023)

Human primed ILCPs support endothelial activation through NF-κB signaling
por: Vanoni, Giulia, et al.
Publicado: (2021)

Antiproliferative and Proapoptotic Effects of Erucin, A Diet-Derived H(2)S Donor, on Human Melanoma Cells
por: Maresca, Daniela Claudia, et al.
Publicado: (2022)

c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells
por: Trabanelli, Sara, et al.
Publicado: (2022)

A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer
por: Kandalaft, Lana E, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2brds43ej3jtfgd2b134u41ifb