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TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration

The G4C2 hexanucleotide repeat expansion mutation in the C9orf72 gene is the most common genetic cause underlying both amyotrophic lateral sclerosis and frontotemporal dementia. Pathologically, these two neurodegenerative disorders are linked by the common presence of abnormal phosphorylated TDP-43...

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Detalles Bibliográficos
Autores principales:	Lee, Samuel M, Asress, Seneshaw, Hales, Chadwick M, Gearing, Marla, Vizcarra, Juan C, Fournier, Christina N, Gutman, David A, Chin, Lih-Shen, Li, Lian, Glass, Jonathan D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788139/ https://www.ncbi.nlm.nih.gov/pubmed/31633109 http://dx.doi.org/10.1093/braincomms/fcz014

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