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Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review

The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, damaged and diseased tissues and organs can be regenerated or...

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Autores principales: Dzobo, Kevin, Motaung, Keolebogile Shirley Caroline M., Adesida, Adetola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788195/
https://www.ncbi.nlm.nih.gov/pubmed/31540457
http://dx.doi.org/10.3390/ijms20184628
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author Dzobo, Kevin
Motaung, Keolebogile Shirley Caroline M.
Adesida, Adetola
author_facet Dzobo, Kevin
Motaung, Keolebogile Shirley Caroline M.
Adesida, Adetola
author_sort Dzobo, Kevin
collection PubMed
description The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, damaged and diseased tissues and organs can be regenerated or created using different configurations and combinations of extracellular matrix (ECM), cells, and inductive biomolecules. Regenerative medicine and tissue engineering can allow the improvement of patients’ quality of life through availing novel treatment options. The coupling of regenerative medicine and tissue engineering with 3D printing, big data, and computational algorithms is revolutionizing the treatment of patients in a huge way. 3D bioprinting allows the proper placement of cells and ECMs, allowing the recapitulation of native microenvironments of tissues and organs. 3D bioprinting utilizes different bioinks made up of different formulations of ECM/biomaterials, biomolecules, and even cells. The choice of the bioink used during 3D bioprinting is very important as properties such as printability, compatibility, and physical strength influence the final construct printed. The extracellular matrix (ECM) provides both physical and mechanical microenvironment needed by cells to survive and proliferate. Decellularized ECM bioink contains biochemical cues from the original native ECM and also the right proportions of ECM proteins. Different techniques and characterization methods are used to derive bioinks from several tissues and organs and to evaluate their quality. This review discusses the uses of decellularized ECM bioinks and argues that they represent the most biomimetic bioinks available. In addition, we briefly discuss some polymer-based bioinks utilized in 3D bioprinting.
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spelling pubmed-67881952019-10-16 Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review Dzobo, Kevin Motaung, Keolebogile Shirley Caroline M. Adesida, Adetola Int J Mol Sci Review The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, damaged and diseased tissues and organs can be regenerated or created using different configurations and combinations of extracellular matrix (ECM), cells, and inductive biomolecules. Regenerative medicine and tissue engineering can allow the improvement of patients’ quality of life through availing novel treatment options. The coupling of regenerative medicine and tissue engineering with 3D printing, big data, and computational algorithms is revolutionizing the treatment of patients in a huge way. 3D bioprinting allows the proper placement of cells and ECMs, allowing the recapitulation of native microenvironments of tissues and organs. 3D bioprinting utilizes different bioinks made up of different formulations of ECM/biomaterials, biomolecules, and even cells. The choice of the bioink used during 3D bioprinting is very important as properties such as printability, compatibility, and physical strength influence the final construct printed. The extracellular matrix (ECM) provides both physical and mechanical microenvironment needed by cells to survive and proliferate. Decellularized ECM bioink contains biochemical cues from the original native ECM and also the right proportions of ECM proteins. Different techniques and characterization methods are used to derive bioinks from several tissues and organs and to evaluate their quality. This review discusses the uses of decellularized ECM bioinks and argues that they represent the most biomimetic bioinks available. In addition, we briefly discuss some polymer-based bioinks utilized in 3D bioprinting. MDPI 2019-09-18 /pmc/articles/PMC6788195/ /pubmed/31540457 http://dx.doi.org/10.3390/ijms20184628 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dzobo, Kevin
Motaung, Keolebogile Shirley Caroline M.
Adesida, Adetola
Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
title Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
title_full Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
title_fullStr Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
title_full_unstemmed Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
title_short Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
title_sort recent trends in decellularized extracellular matrix bioinks for 3d printing: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788195/
https://www.ncbi.nlm.nih.gov/pubmed/31540457
http://dx.doi.org/10.3390/ijms20184628
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