Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor

A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The...

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Detalles Bibliográficos
Autores principales: Jure, Ignacio, De Nicola, Alejandro F., Labombarda, Florencia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788243/
https://www.ncbi.nlm.nih.gov/pubmed/31397329
http://dx.doi.org/10.4103/1673-5374.262570
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author Jure, Ignacio
De Nicola, Alejandro F.
Labombarda, Florencia
author_facet Jure, Ignacio
De Nicola, Alejandro F.
Labombarda, Florencia
author_sort Jure, Ignacio
collection PubMed
description A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.
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spelling pubmed-67882432019-10-16 Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor Jure, Ignacio De Nicola, Alejandro F. Labombarda, Florencia Neural Regen Res Review A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment. Wolters Kluwer - Medknow 2019-08-07 /pmc/articles/PMC6788243/ /pubmed/31397329 http://dx.doi.org/10.4103/1673-5374.262570 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Jure, Ignacio
De Nicola, Alejandro F.
Labombarda, Florencia
Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
title Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
title_full Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
title_fullStr Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
title_full_unstemmed Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
title_short Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
title_sort progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788243/
https://www.ncbi.nlm.nih.gov/pubmed/31397329
http://dx.doi.org/10.4103/1673-5374.262570
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