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Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain
Objective: The information about the epidemiology of Pneumocystis pneumonia (PcP) in Europe is scarce, and in Spain there are only data nationwide on patients with HIV infection. This study has been carried out with the aim of knowing in our country the current epidemiological spectrum and the risk...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788256/ https://www.ncbi.nlm.nih.gov/pubmed/31637227 http://dx.doi.org/10.3389/fpubh.2019.00275 |
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author | Pereira-Díaz, Estefanía Moreno-Verdejo, Fidel de la Horra, Carmen Guerrero, José A. Calderón, Enrique J. Medrano, Francisco J. |
author_facet | Pereira-Díaz, Estefanía Moreno-Verdejo, Fidel de la Horra, Carmen Guerrero, José A. Calderón, Enrique J. Medrano, Francisco J. |
author_sort | Pereira-Díaz, Estefanía |
collection | PubMed |
description | Objective: The information about the epidemiology of Pneumocystis pneumonia (PcP) in Europe is scarce, and in Spain there are only data nationwide on patients with HIV infection. This study has been carried out with the aim of knowing in our country the current epidemiological spectrum and the risk factors of PcP. Methods: Observational, descriptive transversal study that included all patients admitted in Spain with diagnosis upon discharge of PcP registered in the National Health System's Hospital Discharge Records Database of Spain, between 2008 and 2012. Results: Four thousand five hundred and fifty four cases of PcP were reported, 1,204 (26.4%) in HIV-negative patients. During the study period, mean annual incidence (cases per million) was 19.4, remaining globally stable, increasing from 4.4 to 6.3 in HIV-negative patients and decreasing from 15.5 to 13.4 among HIV-infected patients. Risk factors were identified in 85.5% of HIV-negative cases, the most frequent being hematological neoplams (29%), chronic lung diseases (15.9%), and non-hematological cancers (14.9%). Mean mortality and hospitalization cost were high (25.5% and 12,000 euros, respectively). Conclusions: The results of this first nationwide study in Spain allow a change in the misconception that, after the AIDS epidemic, PcP is an infrequent disease, showing that today it is an emerging problem in patients without HIV infection. These findings underlines the need for increased efforts toward a better characterization of risk groups to improve prophylactic strategies and reduce the burden of disease. |
format | Online Article Text |
id | pubmed-6788256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67882562019-10-21 Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain Pereira-Díaz, Estefanía Moreno-Verdejo, Fidel de la Horra, Carmen Guerrero, José A. Calderón, Enrique J. Medrano, Francisco J. Front Public Health Public Health Objective: The information about the epidemiology of Pneumocystis pneumonia (PcP) in Europe is scarce, and in Spain there are only data nationwide on patients with HIV infection. This study has been carried out with the aim of knowing in our country the current epidemiological spectrum and the risk factors of PcP. Methods: Observational, descriptive transversal study that included all patients admitted in Spain with diagnosis upon discharge of PcP registered in the National Health System's Hospital Discharge Records Database of Spain, between 2008 and 2012. Results: Four thousand five hundred and fifty four cases of PcP were reported, 1,204 (26.4%) in HIV-negative patients. During the study period, mean annual incidence (cases per million) was 19.4, remaining globally stable, increasing from 4.4 to 6.3 in HIV-negative patients and decreasing from 15.5 to 13.4 among HIV-infected patients. Risk factors were identified in 85.5% of HIV-negative cases, the most frequent being hematological neoplams (29%), chronic lung diseases (15.9%), and non-hematological cancers (14.9%). Mean mortality and hospitalization cost were high (25.5% and 12,000 euros, respectively). Conclusions: The results of this first nationwide study in Spain allow a change in the misconception that, after the AIDS epidemic, PcP is an infrequent disease, showing that today it is an emerging problem in patients without HIV infection. These findings underlines the need for increased efforts toward a better characterization of risk groups to improve prophylactic strategies and reduce the burden of disease. Frontiers Media S.A. 2019-10-04 /pmc/articles/PMC6788256/ /pubmed/31637227 http://dx.doi.org/10.3389/fpubh.2019.00275 Text en Copyright © 2019 Pereira-Díaz, Moreno-Verdejo, de la Horra, Guerrero, Calderón and Medrano. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Pereira-Díaz, Estefanía Moreno-Verdejo, Fidel de la Horra, Carmen Guerrero, José A. Calderón, Enrique J. Medrano, Francisco J. Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain |
title | Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain |
title_full | Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain |
title_fullStr | Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain |
title_full_unstemmed | Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain |
title_short | Changing Trends in the Epidemiology and Risk Factors of Pneumocystis Pneumonia in Spain |
title_sort | changing trends in the epidemiology and risk factors of pneumocystis pneumonia in spain |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788256/ https://www.ncbi.nlm.nih.gov/pubmed/31637227 http://dx.doi.org/10.3389/fpubh.2019.00275 |
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