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Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis
Thrombotic Thrombocytopenic Purpura (TTP) is a poorly understood entity involving multiple organs and having grave prognosis if not treated promptly. Acute pancreatitis (AP) is a rare cause of TTP and TTP is also a rare complication of acute pancreatitis. TTP is induced in AP by poorly understood me...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788364/ https://www.ncbi.nlm.nih.gov/pubmed/31633051 http://dx.doi.org/10.1002/jgh3.12156 |
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author | Shah, Jimil Mandavdhare, Harshal S Birda, Chhagan Lal Dutta, Usha Sharma, Vishal |
author_facet | Shah, Jimil Mandavdhare, Harshal S Birda, Chhagan Lal Dutta, Usha Sharma, Vishal |
author_sort | Shah, Jimil |
collection | PubMed |
description | Thrombotic Thrombocytopenic Purpura (TTP) is a poorly understood entity involving multiple organs and having grave prognosis if not treated promptly. Acute pancreatitis (AP) is a rare cause of TTP and TTP is also a rare complication of acute pancreatitis. TTP is induced in AP by poorly understood mechanism, which involves multiple pathways apart from only ADAMTS13 deficiency. Here, we report a case of a 32‐year‐old male who developed acute pancreatitis due to chronic alcoholism. He developed signs of TTP from Day 4 of his onset of pain. High clinical suspicion and prompt initiation of plasmapheresis was associated with good outcome. In this case report, we have discussed details of our case and the different mechanisms involved in pathogenesis of TTP in AP and their outcome with prompt management. |
format | Online Article Text |
id | pubmed-6788364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-67883642019-10-18 Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis Shah, Jimil Mandavdhare, Harshal S Birda, Chhagan Lal Dutta, Usha Sharma, Vishal JGH Open Case Reports Thrombotic Thrombocytopenic Purpura (TTP) is a poorly understood entity involving multiple organs and having grave prognosis if not treated promptly. Acute pancreatitis (AP) is a rare cause of TTP and TTP is also a rare complication of acute pancreatitis. TTP is induced in AP by poorly understood mechanism, which involves multiple pathways apart from only ADAMTS13 deficiency. Here, we report a case of a 32‐year‐old male who developed acute pancreatitis due to chronic alcoholism. He developed signs of TTP from Day 4 of his onset of pain. High clinical suspicion and prompt initiation of plasmapheresis was associated with good outcome. In this case report, we have discussed details of our case and the different mechanisms involved in pathogenesis of TTP in AP and their outcome with prompt management. Wiley Publishing Asia Pty Ltd 2019-02-28 /pmc/articles/PMC6788364/ /pubmed/31633051 http://dx.doi.org/10.1002/jgh3.12156 Text en © 2019 Post Graduate Institute of Medical Education and Research, Chandigarh, India. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Reports Shah, Jimil Mandavdhare, Harshal S Birda, Chhagan Lal Dutta, Usha Sharma, Vishal Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis |
title | Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis |
title_full | Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis |
title_fullStr | Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis |
title_full_unstemmed | Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis |
title_short | Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis |
title_sort | thrombotic thrombocytopenic purpura: a rare complication of acute pancreatitis |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788364/ https://www.ncbi.nlm.nih.gov/pubmed/31633051 http://dx.doi.org/10.1002/jgh3.12156 |
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