Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors

Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between bre...

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Autores principales: Miaskowski, Christine, Topp, Kimberly, Conley, Yvette P., Paul, Steven M., Melisko, Michelle, Schumacher, Mark, Chesney, Margaret, Abrams, Gary, Levine, Jon D., Kober, Kord M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788784/
https://www.ncbi.nlm.nih.gov/pubmed/31401418
http://dx.doi.org/10.1016/j.jneuroim.2019.577019
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author Miaskowski, Christine
Topp, Kimberly
Conley, Yvette P.
Paul, Steven M.
Melisko, Michelle
Schumacher, Mark
Chesney, Margaret
Abrams, Gary
Levine, Jon D.
Kober, Kord M.
author_facet Miaskowski, Christine
Topp, Kimberly
Conley, Yvette P.
Paul, Steven M.
Melisko, Michelle
Schumacher, Mark
Chesney, Margaret
Abrams, Gary
Levine, Jon D.
Kober, Kord M.
author_sort Miaskowski, Christine
collection PubMed
description Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between breast cancer survivors with and without PIPN and for neuroinflammatory (NI) related signaling pathways and whole-transcriptome profiles from other experiments. Pathway impact analysis identified 8 perturbed NI related pathways. Expression profile analysis found 15 experiments having similar whole-transcriptome profiles of DGE related to neuroinflammation and PIPN. These findings suggest that perturbations in pathways associated with neuroinflammation are found in cancer survivors with PIPN.
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spelling pubmed-67887842020-04-02 Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors Miaskowski, Christine Topp, Kimberly Conley, Yvette P. Paul, Steven M. Melisko, Michelle Schumacher, Mark Chesney, Margaret Abrams, Gary Levine, Jon D. Kober, Kord M. J Neuroimmunol Article Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between breast cancer survivors with and without PIPN and for neuroinflammatory (NI) related signaling pathways and whole-transcriptome profiles from other experiments. Pathway impact analysis identified 8 perturbed NI related pathways. Expression profile analysis found 15 experiments having similar whole-transcriptome profiles of DGE related to neuroinflammation and PIPN. These findings suggest that perturbations in pathways associated with neuroinflammation are found in cancer survivors with PIPN. Elsevier B.V. 2019-10-15 2019-08-02 /pmc/articles/PMC6788784/ /pubmed/31401418 http://dx.doi.org/10.1016/j.jneuroim.2019.577019 Text en © 2019 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Miaskowski, Christine
Topp, Kimberly
Conley, Yvette P.
Paul, Steven M.
Melisko, Michelle
Schumacher, Mark
Chesney, Margaret
Abrams, Gary
Levine, Jon D.
Kober, Kord M.
Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
title Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
title_full Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
title_fullStr Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
title_full_unstemmed Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
title_short Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
title_sort perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788784/
https://www.ncbi.nlm.nih.gov/pubmed/31401418
http://dx.doi.org/10.1016/j.jneuroim.2019.577019
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