Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

Niemann Pick Type-C disease (NPC) is an inherited lysosomal storage disease (LSD) caused by pathogenic variants in the Npc1 or Npc2 genes that lead to the accumulation of cholesterol and lipids in lysosomes. NPC1 deficiency causes neurodegeneration, dementia and early death. Cerebellar Purkinje cell...

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Detalles Bibliográficos
Autores principales: Kavetsky, Larisa, Green, Kayla K., Boyle, Bridget R., Yousufzai, Fawad A. K., Padron, Zachary M., Melli, Sierra E., Kuhnel, Victoria L., Jackson, Harriet M., Blanco, Rosa E., Howell, Gareth R., Soto, Ileana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788982/
https://www.ncbi.nlm.nih.gov/pubmed/31605022
http://dx.doi.org/10.1038/s41598-019-51246-1

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