Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Isocitrate lyase is important for lipid utilisation by Mycobacterium tuberculosis but its ICL2 isoform is poorly understood. Here we report that binding of the lipid metabolites acetyl-CoA or propionyl-CoA to ICL2 induces a striking structural rearrangement, substantially increasing isocitrate lyase...

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Detalles Bibliográficos
Autores principales: Bhusal, Ram Prasad, Jiao, Wanting, Kwai, Brooke X. C., Reynisson, Jóhannes, Collins, Annabelle J., Sperry, Jonathan, Bashiri, Ghader, Leung, Ivanhoe K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788997/
https://www.ncbi.nlm.nih.gov/pubmed/31604954
http://dx.doi.org/10.1038/s41467-019-12614-7

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