Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive assays for assessing transcription factor activity are lacking. Here we develop and validate a minimally invasive method for assessing TF activity based on cell-free DNA sequencing and nucleosome fo...

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Detalles Bibliográficos
Autores principales: Ulz, Peter, Perakis, Samantha, Zhou, Qing, Moser, Tina, Belic, Jelena, Lazzeri, Isaac, Wölfler, Albert, Zebisch, Armin, Gerger, Armin, Pristauz, Gunda, Petru, Edgar, White, Brandon, Roberts, Charles E. S., John, John St., Schimek, Michael G., Geigl, Jochen B., Bauernhofer, Thomas, Sill, Heinz, Bock, Christoph, Heitzer, Ellen, Speicher, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789008/
https://www.ncbi.nlm.nih.gov/pubmed/31604930
http://dx.doi.org/10.1038/s41467-019-12714-4

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