Individualized recovery of gut microbial strains post antibiotics

To further understand the impact of antibiotics on the gastrointestinal tract microbial community, the intra-individual recovery pattern of specific microbial strains was determined using metagenomic sequencing coupled with strain-tracking analyses. In a study where 18 individuals were administered...

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Detalles Bibliográficos
Autores principales: Koo, Hyunmin, Hakim, Joseph A., Crossman, David K., Kumar, Ranjit, Lefkowitz, Elliot J., Morrow, Casey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789009/
https://www.ncbi.nlm.nih.gov/pubmed/31632686
http://dx.doi.org/10.1038/s41522-019-0103-8
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author Koo, Hyunmin
Hakim, Joseph A.
Crossman, David K.
Kumar, Ranjit
Lefkowitz, Elliot J.
Morrow, Casey D.
author_facet Koo, Hyunmin
Hakim, Joseph A.
Crossman, David K.
Kumar, Ranjit
Lefkowitz, Elliot J.
Morrow, Casey D.
author_sort Koo, Hyunmin
collection PubMed
description To further understand the impact of antibiotics on the gastrointestinal tract microbial community, the intra-individual recovery pattern of specific microbial strains was determined using metagenomic sequencing coupled with strain-tracking analyses. In a study where 18 individuals were administered a single antibiotic (cefprozil), new microbial genomic variants (herein strains) were transiently detected in 15 individuals, while in a second study that used a cocktail of three antibiotics (meropenem, gentamicin, and vancomycin), all 12 participants had either permanent or transient strain changes. The presence of distinct microbial genomic variants indicates a pattern of strain recovery that is intra-individual specific following disruption of the human gastrointestinal tract with antibiotics.
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spelling pubmed-67890092019-10-18 Individualized recovery of gut microbial strains post antibiotics Koo, Hyunmin Hakim, Joseph A. Crossman, David K. Kumar, Ranjit Lefkowitz, Elliot J. Morrow, Casey D. NPJ Biofilms Microbiomes Brief Communication To further understand the impact of antibiotics on the gastrointestinal tract microbial community, the intra-individual recovery pattern of specific microbial strains was determined using metagenomic sequencing coupled with strain-tracking analyses. In a study where 18 individuals were administered a single antibiotic (cefprozil), new microbial genomic variants (herein strains) were transiently detected in 15 individuals, while in a second study that used a cocktail of three antibiotics (meropenem, gentamicin, and vancomycin), all 12 participants had either permanent or transient strain changes. The presence of distinct microbial genomic variants indicates a pattern of strain recovery that is intra-individual specific following disruption of the human gastrointestinal tract with antibiotics. Nature Publishing Group UK 2019-10-11 /pmc/articles/PMC6789009/ /pubmed/31632686 http://dx.doi.org/10.1038/s41522-019-0103-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Koo, Hyunmin
Hakim, Joseph A.
Crossman, David K.
Kumar, Ranjit
Lefkowitz, Elliot J.
Morrow, Casey D.
Individualized recovery of gut microbial strains post antibiotics
title Individualized recovery of gut microbial strains post antibiotics
title_full Individualized recovery of gut microbial strains post antibiotics
title_fullStr Individualized recovery of gut microbial strains post antibiotics
title_full_unstemmed Individualized recovery of gut microbial strains post antibiotics
title_short Individualized recovery of gut microbial strains post antibiotics
title_sort individualized recovery of gut microbial strains post antibiotics
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789009/
https://www.ncbi.nlm.nih.gov/pubmed/31632686
http://dx.doi.org/10.1038/s41522-019-0103-8
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