Cargando…

Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus

Elucidating the genetic basis of metabolic resistance to insecticides in malaria vectors is crucial to prolonging the effectiveness of insecticide-based control tools including long lasting insecticidal nets (LLINs). Here, we show that cis-regulatory variants of the cytochrome P450 gene, CYP6P9b, ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mugenzi, Leon M. J., Menze, Benjamin D., Tchouakui, Magellan, Wondji, Murielle J., Irving, Helen, Tchoupo, Micareme, Hearn, Jack, Weedall, Gareth D., Riveron, Jacob M., Wondji, Charles S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789023/ https://www.ncbi.nlm.nih.gov/pubmed/31604938 http://dx.doi.org/10.1038/s41467-019-12686-5

Ejemplares similares

Combined over-expression of two cytochrome P450 genes exacerbates the fitness cost of pyrethroid resistance in the major African malaria vector Anopheles funestus
por: Tchouakui, Magellan, et al.
Publicado: (2021)

Experimental Hut Trials Reveal That CYP6P9a/b P450 Alleles Are Reducing the Efficacy of Pyrethroid-Only Olyset Net against the Malaria Vector Anopheles funestus but PBO-Based Olyset Plus Net Remains Effective
por: Menze, Benjamin D., et al.
Publicado: (2022)

A 6.5kb Intergenic Structural Variation Exacerbates the Fitness Cost of P450-Based Metabolic Resistance in the Major African Malaria Vector Anopheles funestus
por: Tchouakui, Magellan, et al.
Publicado: (2022)

Correction: Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus
por: Tchouakui, Magellan, et al.
Publicado: (2020)

Escalation of Pyrethroid Resistance in the Malaria Vector Anopheles funestus Induces a Loss of Efficacy of Piperonyl Butoxide–Based Insecticide-Treated Nets in Mozambique
por: Riveron, Jacob M, et al.
Publicado: (2019)

A marker of glutathione S-transferase-mediated resistance to insecticides is associated with higher Plasmodium infection in the African malaria vector Anopheles funestus
por: Tchouakui, Magellan, et al.
Publicado: (2019)

Escalating pyrethroid resistance in two major malaria vectors Anopheles funestus and Anopheles gambiae (s.l.) in Atatam, Southern Ghana
por: Mugenzi, Leon M. J., et al.
Publicado: (2022)

Marked aggravation of pyrethroid resistance in major malaria vectors in Malawi between 2014 and 2021 is partly linked with increased expression of P450 alleles
por: Menze, Benjamin D., et al.
Publicado: (2022)

RNAseq-based gene expression profiling of the Anopheles funestus pyrethroid-resistant strain FUMOZ highlights the predominant role of the duplicated CYP6P9a/b cytochrome P450s
por: Wondji, Charles S, et al.
Publicado: (2021)

High insecticide resistance in the major malaria vector Anopheles coluzzii in Chad Republic
por: Ibrahim, Sulaiman S., et al.
Publicado: (2019)

CYP6P9-Driven Signatures of Selective Sweep of Metabolic Resistance to Pyrethroids in the Malaria Vector Anopheles funestus Reveal Contemporary Barriers to Gene Flow
por: Djuicy, Delia Doreen, et al.
Publicado: (2020)

Reduced performance of community bednets against pyrethroid-resistant Anopheles funestus and Anopheles gambiae, major malaria vectors in Cameroon
por: Ngongang-Yipmo, Emilie S., et al.
Publicado: (2022)

The duplicated P450s CYP6P9a/b drive carbamates and pyrethroids cross-resistance in the major African malaria vector Anopheles funestus
por: Mugenzi, Leon M. J., et al.
Publicado: (2023)

An Experimental Hut Evaluation of PBO-Based and Pyrethroid-Only Nets against the Malaria Vector Anopheles funestus Reveals a Loss of Bed Nets Efficacy Associated with GSTe2 Metabolic Resistance
por: Menze, Benjamin D., et al.
Publicado: (2020)

Pyrethroid Resistance Aggravation in Ugandan Malaria Vectors Is Reducing Bednet Efficacy
por: Tchouakui, Magellan, et al.
Publicado: (2021)

Genome-Wide Transcriptional Analysis and Functional Validation Linked a Cluster of Epsilon Glutathione S-Transferases with Insecticide Resistance in the Major Malaria Vector Anopheles funestus across Africa
por: Kouamo, Mersimine F. M., et al.
Publicado: (2021)

Pyrethroid Resistance in the Major Malaria Vector Anopheles funestus is Exacerbated by Overexpression and Overactivity of the P450 CYP6AA1 Across Africa
por: Ibrahim, Sulaiman S., et al.
Publicado: (2018)

Bionomics and insecticides resistance profiling of malaria vectors at a selected site for experimental hut trials in central Cameroon
por: Menze, Benjamin D., et al.
Publicado: (2018)

Anopheles funestus Populations across Africa Are Broadly Susceptible to Neonicotinoids but with Signals of Possible Cross-Resistance from the GSTe2 Gene
por: Assatse, Tatiane, et al.
Publicado: (2023)

Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control
por: Riveron, Jacob M., et al.
Publicado: (2015)

Gene Conversion Explains Elevated Diversity in the Immunity Modulating APL1 Gene of the Malaria Vector Anopheles funestus
por: Hearn, Jack, et al.
Publicado: (2022)

A combination of metabolic resistance and high frequency of the 1014F kdr mutation is driving pyrethroid resistance in Anopheles coluzzii population from Guinea savanna of Cameroon
por: Fadel, Amen N., et al.
Publicado: (2019)

Fitness Costs of the Glutathione S-Transferase Epsilon 2 (L119F-GSTe2) Mediated Metabolic Resistance to Insecticides in the Major African Malaria Vector Anopheles Funestus
por: Tchouakui, Magellan, et al.
Publicado: (2018)

Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vector Anopheles funestus
por: Nouage, Lynda, et al.
Publicado: (2020)

Xeno-monitoring of molecular drivers of artemisinin and partner drug resistance in P. falciparum populations in malaria vectors across Cameroon
por: Nkemngo, Francis N., et al.
Publicado: (2022)

An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons
por: Weedall, Gareth D., et al.
Publicado: (2020)

Contrasting Patterns of Asaia Association with Pyrethroid Resistance Escalation between the Malaria Vectors Anopheles funestus and Anopheles gambiae
por: Djondji Kamga, Fleuriane Metissa, et al.
Publicado: (2023)

Detection of a reduced susceptibility to chlorfenapyr in the malaria vector Anopheles gambiae contrasts with full susceptibility in Anopheles funestus across Africa
por: Tchouakui, Magellan, et al.
Publicado: (2023)

Multi‐omics analysis identifies a CYP9K1 haplotype conferring pyrethroid resistance in the malaria vector Anopheles funestus in East Africa
por: Hearn, Jack, et al.
Publicado: (2022)

Multiple insecticide resistance and Plasmodium infection in the principal malaria vectors Anopheles funestus and Anopheles gambiae in a forested locality close to the Yaoundé airport, Cameroon
por: Nkemngo, Francis N., et al.
Publicado: (2020)

Functional characterisation of cytochrome P450s involved in insecticide resistance in major malaria vector Anopheles funestus across Africa
por: Wondji, Charles, et al.
Publicado: (2014)

Fitness cost of target-site and metabolic resistance to pyrethroids drives restoration of susceptibility in a highly resistant Anopheles gambiae population from Uganda
por: Tchouakui, Magellan, et al.
Publicado: (2022)

Exposure to the insecticide-treated bednet PermaNet 2.0 reduces the longevity of the wild African malaria vector Anopheles funestus but GSTe2-resistant mosquitoes live longer
por: Tchakounte, Ange, et al.
Publicado: (2019)

Entomological longitudinal surveys in two contrasted eco-climatic settings in Cameroon reveal a high malaria transmission from Anopheles funestus associated with GSTe2 metabolic resistance
por: Natchema S. Fonkou, Brice, et al.
Publicado: (2023)

Multiple insecticide resistance in the major malaria vector Anopheles funestus in southern Ghana: implications for malaria control
por: Riveron, Jacob M., et al.
Publicado: (2016)

Multiple Insecticide Resistance in the Malaria Vector Anopheles funestus from Northern Cameroon Is Mediated by Metabolic Resistance Alongside Potential Target Site Insensitivity Mutations
por: Menze, Benjamin D., et al.
Publicado: (2016)

Multiple insecticide resistance in an infected population of the malaria vector Anopheles funestus in Benin
por: Djouaka, Rousseau, et al.
Publicado: (2016)

Exploring Mechanisms of Multiple Insecticide Resistance in a Population of the Malaria Vector Anopheles funestus in Benin
por: Djouaka, Rousseau, et al.
Publicado: (2011)

Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus
por: Irving, H, et al.
Publicado: (2012)

Evidence of a multiple insecticide resistance in the malaria vector Anopheles funestus in South West Nigeria
por: Djouaka, Rousseau J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_oiavur23dgrvjsdgvfrre92v6p