Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility

Infertility in men and women is a complex genetic trait with shared biological bases between the sexes. Here, we perform a series of rare variant analyses across 73,185 women and men to identify genes that contribute to primary gonadal dysfunction. We report CSMD1, a complement regulatory protein on...

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Detalles Bibliográficos
Autores principales: Lee, Arthur S., Rusch, Jannette, Lima, Ana C., Usmani, Abul, Huang, Ni, Lepamets, Maarja, Vigh-Conrad, Katinka A., Worthington, Ronald E., Mägi, Reedik, Wu, Xiaobo, Aston, Kenneth I., Atkinson, John P., Carrell, Douglas T., Hess, Rex A., O’Bryan, Moira K., Conrad, Donald F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789153/
https://www.ncbi.nlm.nih.gov/pubmed/31604923
http://dx.doi.org/10.1038/s41467-019-12522-w

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