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Inhibition of spindle extension through the yeast S phase checkpoint is coupled to replication fork stability and the integrity of centromeric DNA

Budding yeast treated with hydroxyurea (HU) activate the S phase checkpoint kinase Rad53, which prevents DNA replication forks from undergoing aberrant structural transitions and nuclease processing. Rad53 is also required to prevent premature extension of the mitotic spindle that assembles during a...

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Detalles Bibliográficos
Autores principales:	Julius, Jeff, Peng, Jie, McCulley, Andrew, Caridi, Chris, Arnak, Remigiusz, See, Colby, Nugent, Constance I., Feng, Wenyi, Bachant, Jeff
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789157/ https://www.ncbi.nlm.nih.gov/pubmed/31509480 http://dx.doi.org/10.1091/mbc.E19-03-0156

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