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Using induced pluripotent stem cells for modeling Parkinson’s disease

Parkinson’s disease (PD) is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. As DA neurons degenerate, PD patients gradually lose their ability of movement. To date no effective therapies are available for the treatment of...

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Autores principales: Ke, Minjing, Chong, Cheong-Meng, Su, Huanxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789186/
https://www.ncbi.nlm.nih.gov/pubmed/31616540
http://dx.doi.org/10.4252/wjsc.v11.i9.634
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author Ke, Minjing
Chong, Cheong-Meng
Su, Huanxing
author_facet Ke, Minjing
Chong, Cheong-Meng
Su, Huanxing
author_sort Ke, Minjing
collection PubMed
description Parkinson’s disease (PD) is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. As DA neurons degenerate, PD patients gradually lose their ability of movement. To date no effective therapies are available for the treatment of PD and its pathogenesis remains unknown. Experimental models that appropriately mimic the development of PD are certainly needed for gaining mechanistic insights into PD pathogenesis and identifying new therapeutic targets. Human induced pluripotent stem cells (iPSCs) could provide a promising model for fundamental research and drug screening. In this review, we summarize various iPSCs-based PD models either derived from PD patients through reprogramming technology or established by gene-editing technology, and the promising application of iPSC-based PD models for mechanistic studies and drug testing.
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spelling pubmed-67891862019-10-15 Using induced pluripotent stem cells for modeling Parkinson’s disease Ke, Minjing Chong, Cheong-Meng Su, Huanxing World J Stem Cells Review Parkinson’s disease (PD) is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. As DA neurons degenerate, PD patients gradually lose their ability of movement. To date no effective therapies are available for the treatment of PD and its pathogenesis remains unknown. Experimental models that appropriately mimic the development of PD are certainly needed for gaining mechanistic insights into PD pathogenesis and identifying new therapeutic targets. Human induced pluripotent stem cells (iPSCs) could provide a promising model for fundamental research and drug screening. In this review, we summarize various iPSCs-based PD models either derived from PD patients through reprogramming technology or established by gene-editing technology, and the promising application of iPSC-based PD models for mechanistic studies and drug testing. Baishideng Publishing Group Inc 2019-09-26 2019-09-26 /pmc/articles/PMC6789186/ /pubmed/31616540 http://dx.doi.org/10.4252/wjsc.v11.i9.634 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Ke, Minjing
Chong, Cheong-Meng
Su, Huanxing
Using induced pluripotent stem cells for modeling Parkinson’s disease
title Using induced pluripotent stem cells for modeling Parkinson’s disease
title_full Using induced pluripotent stem cells for modeling Parkinson’s disease
title_fullStr Using induced pluripotent stem cells for modeling Parkinson’s disease
title_full_unstemmed Using induced pluripotent stem cells for modeling Parkinson’s disease
title_short Using induced pluripotent stem cells for modeling Parkinson’s disease
title_sort using induced pluripotent stem cells for modeling parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789186/
https://www.ncbi.nlm.nih.gov/pubmed/31616540
http://dx.doi.org/10.4252/wjsc.v11.i9.634
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