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Bioactive lipids in cancer stem cells
Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789187/ https://www.ncbi.nlm.nih.gov/pubmed/31616544 http://dx.doi.org/10.4252/wjsc.v11.i9.693 |
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author | Begicevic, Romana-Rea Arfuso, Frank Falasca, Marco |
author_facet | Begicevic, Romana-Rea Arfuso, Frank Falasca, Marco |
author_sort | Begicevic, Romana-Rea |
collection | PubMed |
description | Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and radiotherapy. In recent years, the role of lipid metabolism has garnered increasing attention in cancer. Specifically, the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs, have gained particular interest. However, despite accumulating evidence on the role of proteins in controlling lipid metabolism, very little is known about the specific role played by lipid products in CSCs. This review highlights recent findings on the role of lipid metabolism in CSCs, focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways. |
format | Online Article Text |
id | pubmed-6789187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-67891872019-10-15 Bioactive lipids in cancer stem cells Begicevic, Romana-Rea Arfuso, Frank Falasca, Marco World J Stem Cells Review Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and radiotherapy. In recent years, the role of lipid metabolism has garnered increasing attention in cancer. Specifically, the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs, have gained particular interest. However, despite accumulating evidence on the role of proteins in controlling lipid metabolism, very little is known about the specific role played by lipid products in CSCs. This review highlights recent findings on the role of lipid metabolism in CSCs, focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways. Baishideng Publishing Group Inc 2019-09-26 2019-09-26 /pmc/articles/PMC6789187/ /pubmed/31616544 http://dx.doi.org/10.4252/wjsc.v11.i9.693 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Begicevic, Romana-Rea Arfuso, Frank Falasca, Marco Bioactive lipids in cancer stem cells |
title | Bioactive lipids in cancer stem cells |
title_full | Bioactive lipids in cancer stem cells |
title_fullStr | Bioactive lipids in cancer stem cells |
title_full_unstemmed | Bioactive lipids in cancer stem cells |
title_short | Bioactive lipids in cancer stem cells |
title_sort | bioactive lipids in cancer stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789187/ https://www.ncbi.nlm.nih.gov/pubmed/31616544 http://dx.doi.org/10.4252/wjsc.v11.i9.693 |
work_keys_str_mv | AT begicevicromanarea bioactivelipidsincancerstemcells AT arfusofrank bioactivelipidsincancerstemcells AT falascamarco bioactivelipidsincancerstemcells |