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Bioactive lipids in cancer stem cells

Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and...

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Detalles Bibliográficos
Autores principales: Begicevic, Romana-Rea, Arfuso, Frank, Falasca, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789187/
https://www.ncbi.nlm.nih.gov/pubmed/31616544
http://dx.doi.org/10.4252/wjsc.v11.i9.693
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author Begicevic, Romana-Rea
Arfuso, Frank
Falasca, Marco
author_facet Begicevic, Romana-Rea
Arfuso, Frank
Falasca, Marco
author_sort Begicevic, Romana-Rea
collection PubMed
description Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and radiotherapy. In recent years, the role of lipid metabolism has garnered increasing attention in cancer. Specifically, the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs, have gained particular interest. However, despite accumulating evidence on the role of proteins in controlling lipid metabolism, very little is known about the specific role played by lipid products in CSCs. This review highlights recent findings on the role of lipid metabolism in CSCs, focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways.
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spelling pubmed-67891872019-10-15 Bioactive lipids in cancer stem cells Begicevic, Romana-Rea Arfuso, Frank Falasca, Marco World J Stem Cells Review Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and radiotherapy. In recent years, the role of lipid metabolism has garnered increasing attention in cancer. Specifically, the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs, have gained particular interest. However, despite accumulating evidence on the role of proteins in controlling lipid metabolism, very little is known about the specific role played by lipid products in CSCs. This review highlights recent findings on the role of lipid metabolism in CSCs, focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways. Baishideng Publishing Group Inc 2019-09-26 2019-09-26 /pmc/articles/PMC6789187/ /pubmed/31616544 http://dx.doi.org/10.4252/wjsc.v11.i9.693 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Begicevic, Romana-Rea
Arfuso, Frank
Falasca, Marco
Bioactive lipids in cancer stem cells
title Bioactive lipids in cancer stem cells
title_full Bioactive lipids in cancer stem cells
title_fullStr Bioactive lipids in cancer stem cells
title_full_unstemmed Bioactive lipids in cancer stem cells
title_short Bioactive lipids in cancer stem cells
title_sort bioactive lipids in cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789187/
https://www.ncbi.nlm.nih.gov/pubmed/31616544
http://dx.doi.org/10.4252/wjsc.v11.i9.693
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