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Liver re-transplantation for donor-derived neuroendocrine tumor: A case report
BACKGROUND: Donor-origin cancer is a well-recognized but rare complication after liver transplantation (LT). The rise in the use of extended criteria donors due to the current shortage of organs increases the risk. Data on donor-origin neuroendocrine neoplasms (NENs) and the most appropriate treatme...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789388/ https://www.ncbi.nlm.nih.gov/pubmed/31616694 http://dx.doi.org/10.12998/wjcc.v7.i18.2794 |
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author | Mrzljak, Anna Kocman, Branislav Skrtic, Anita Furac, Ivana Popic, Jelena Franusic, Lucija Zunec, Renata Mayer, Davor Mikulic, Danko |
author_facet | Mrzljak, Anna Kocman, Branislav Skrtic, Anita Furac, Ivana Popic, Jelena Franusic, Lucija Zunec, Renata Mayer, Davor Mikulic, Danko |
author_sort | Mrzljak, Anna |
collection | PubMed |
description | BACKGROUND: Donor-origin cancer is a well-recognized but rare complication after liver transplantation (LT). The rise in the use of extended criteria donors due to the current shortage of organs increases the risk. Data on donor-origin neuroendocrine neoplasms (NENs) and the most appropriate treatment are scarce. Here, we report a case of a patient who developed a NEN confined to the liver after LT and was treated with liver re-transplantation (re-LT). CASE SUMMARY: A 49-year-old man with no other medical co-morbidities underwent LT in 2013 for alcoholic liver cirrhosis. The donor was a 73-year-old female with no known malignancies. Early after LT, a hypoechogenic (15 mm) lesion was detected in the left hepatic lobe on abdominal ultrasound. The lesion was stable for next 11 mo, when abdominal magnetic resonance identified two hypovascular lesions (20 and 11 mm) with atypical enhancement pattern. Follow-up abdominal ultrasound revealed no new lesions for the next 2.5 years, when magnetic resonance showed a progression in size and number of lesions, also confirmed by abdominal computed tomography. Liver biopsy proved a well-differentiated NEN. Genetic analysis of the NEN confirmed donor origin of the neoplasm. As NEN was confined to liver graft only, in 2018, the patient underwent his second LT. At 12 mo after re-LT the patient is well with no signs of NEN dissemination. CONCLUSION: The benefits of graft explantation should be weighed against the risks of re-LT and the likelihood of NEN dissemination beyond the graft. |
format | Online Article Text |
id | pubmed-6789388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-67893882019-10-15 Liver re-transplantation for donor-derived neuroendocrine tumor: A case report Mrzljak, Anna Kocman, Branislav Skrtic, Anita Furac, Ivana Popic, Jelena Franusic, Lucija Zunec, Renata Mayer, Davor Mikulic, Danko World J Clin Cases Case Report BACKGROUND: Donor-origin cancer is a well-recognized but rare complication after liver transplantation (LT). The rise in the use of extended criteria donors due to the current shortage of organs increases the risk. Data on donor-origin neuroendocrine neoplasms (NENs) and the most appropriate treatment are scarce. Here, we report a case of a patient who developed a NEN confined to the liver after LT and was treated with liver re-transplantation (re-LT). CASE SUMMARY: A 49-year-old man with no other medical co-morbidities underwent LT in 2013 for alcoholic liver cirrhosis. The donor was a 73-year-old female with no known malignancies. Early after LT, a hypoechogenic (15 mm) lesion was detected in the left hepatic lobe on abdominal ultrasound. The lesion was stable for next 11 mo, when abdominal magnetic resonance identified two hypovascular lesions (20 and 11 mm) with atypical enhancement pattern. Follow-up abdominal ultrasound revealed no new lesions for the next 2.5 years, when magnetic resonance showed a progression in size and number of lesions, also confirmed by abdominal computed tomography. Liver biopsy proved a well-differentiated NEN. Genetic analysis of the NEN confirmed donor origin of the neoplasm. As NEN was confined to liver graft only, in 2018, the patient underwent his second LT. At 12 mo after re-LT the patient is well with no signs of NEN dissemination. CONCLUSION: The benefits of graft explantation should be weighed against the risks of re-LT and the likelihood of NEN dissemination beyond the graft. Baishideng Publishing Group Inc 2019-09-26 2019-09-26 /pmc/articles/PMC6789388/ /pubmed/31616694 http://dx.doi.org/10.12998/wjcc.v7.i18.2794 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Mrzljak, Anna Kocman, Branislav Skrtic, Anita Furac, Ivana Popic, Jelena Franusic, Lucija Zunec, Renata Mayer, Davor Mikulic, Danko Liver re-transplantation for donor-derived neuroendocrine tumor: A case report |
title | Liver re-transplantation for donor-derived neuroendocrine tumor: A case report |
title_full | Liver re-transplantation for donor-derived neuroendocrine tumor: A case report |
title_fullStr | Liver re-transplantation for donor-derived neuroendocrine tumor: A case report |
title_full_unstemmed | Liver re-transplantation for donor-derived neuroendocrine tumor: A case report |
title_short | Liver re-transplantation for donor-derived neuroendocrine tumor: A case report |
title_sort | liver re-transplantation for donor-derived neuroendocrine tumor: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789388/ https://www.ncbi.nlm.nih.gov/pubmed/31616694 http://dx.doi.org/10.12998/wjcc.v7.i18.2794 |
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