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Long Term Effectiveness of Photodynamic Therapy for CIN Treatment

(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16...

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Autores principales: Inada, Natalia Mayumi, Buzzá, Hilde Harb, Leite, Marieli Fernanda Martins, Kurachi, Cristina, Trujillo, Jose Roberto, de Castro, Cynthia Aparecida, Carbinatto, Fernanda Mansano, Lombardi, Welington, Bagnato, Vanderlei Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789515/
https://www.ncbi.nlm.nih.gov/pubmed/31336848
http://dx.doi.org/10.3390/ph12030107
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author Inada, Natalia Mayumi
Buzzá, Hilde Harb
Leite, Marieli Fernanda Martins
Kurachi, Cristina
Trujillo, Jose Roberto
de Castro, Cynthia Aparecida
Carbinatto, Fernanda Mansano
Lombardi, Welington
Bagnato, Vanderlei Salvador
author_facet Inada, Natalia Mayumi
Buzzá, Hilde Harb
Leite, Marieli Fernanda Martins
Kurachi, Cristina
Trujillo, Jose Roberto
de Castro, Cynthia Aparecida
Carbinatto, Fernanda Mansano
Lombardi, Welington
Bagnato, Vanderlei Salvador
author_sort Inada, Natalia Mayumi
collection PubMed
description (1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix.
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spelling pubmed-67895152019-10-16 Long Term Effectiveness of Photodynamic Therapy for CIN Treatment Inada, Natalia Mayumi Buzzá, Hilde Harb Leite, Marieli Fernanda Martins Kurachi, Cristina Trujillo, Jose Roberto de Castro, Cynthia Aparecida Carbinatto, Fernanda Mansano Lombardi, Welington Bagnato, Vanderlei Salvador Pharmaceuticals (Basel) Article (1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix. MDPI 2019-07-12 /pmc/articles/PMC6789515/ /pubmed/31336848 http://dx.doi.org/10.3390/ph12030107 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Inada, Natalia Mayumi
Buzzá, Hilde Harb
Leite, Marieli Fernanda Martins
Kurachi, Cristina
Trujillo, Jose Roberto
de Castro, Cynthia Aparecida
Carbinatto, Fernanda Mansano
Lombardi, Welington
Bagnato, Vanderlei Salvador
Long Term Effectiveness of Photodynamic Therapy for CIN Treatment
title Long Term Effectiveness of Photodynamic Therapy for CIN Treatment
title_full Long Term Effectiveness of Photodynamic Therapy for CIN Treatment
title_fullStr Long Term Effectiveness of Photodynamic Therapy for CIN Treatment
title_full_unstemmed Long Term Effectiveness of Photodynamic Therapy for CIN Treatment
title_short Long Term Effectiveness of Photodynamic Therapy for CIN Treatment
title_sort long term effectiveness of photodynamic therapy for cin treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789515/
https://www.ncbi.nlm.nih.gov/pubmed/31336848
http://dx.doi.org/10.3390/ph12030107
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