Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

To combat emerging infectious diseases like Zika virus (ZIKV), synthetic messenger RNAs (mRNAs) encoding viral antigens are very attractive as they allow a rapid, generic, and flexible production of vaccines. In this work, we engineered a self-replicating mRNA (sr-mRNA) vaccine encoding the pre-memb...

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Detalles Bibliográficos
Autores principales: Zhong, Zifu, Portela Catani, João Paulo, Mc Cafferty, Séan, Couck, Liesbeth, Van Den Broeck, Wim, Gorlé, Nina, Vandenbroucke, Roosmarijn E., Devriendt, Bert, Ulbert, Sebastian, Cnops, Lieselotte, Michels, Johan, Ariën, Kevin K., Sanders, Niek N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789535/
https://www.ncbi.nlm.nih.gov/pubmed/31450775
http://dx.doi.org/10.3390/vaccines7030096

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