Cargando…

Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems

Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of...

Descripción completa

Detalles Bibliográficos
Autores principales: Marchi, Jacopo, Lässig, Michael, Mora, Thierry, Walczak, Aleksandra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789611/
https://www.ncbi.nlm.nih.gov/pubmed/31362404
http://dx.doi.org/10.3390/pathogens8030115
_version_ 1783458659908452352
author Marchi, Jacopo
Lässig, Michael
Mora, Thierry
Walczak, Aleksandra M.
author_facet Marchi, Jacopo
Lässig, Michael
Mora, Thierry
Walczak, Aleksandra M.
author_sort Marchi, Jacopo
collection PubMed
description Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of influenza A and the prolonged coexistence of lineages in influenza B. Here, we use an evolutionary model for viruses in the presence of immune host systems with finite memory to obtain a phase diagram of evolutionary patterns in a two-dimensional antigenic space. We find that, for small effective mutation rates and mutation jump ranges, a single lineage is the only stable solution. Large effective mutation rates combined with large mutational jumps in antigenic space lead to multiple stably co-existing lineages over prolonged evolutionary periods. These results combined with observations from data constrain the parameter regimes for the adaptation of viruses, including influenza.
format Online
Article
Text
id pubmed-6789611
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67896112019-10-16 Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems Marchi, Jacopo Lässig, Michael Mora, Thierry Walczak, Aleksandra M. Pathogens Article Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of influenza A and the prolonged coexistence of lineages in influenza B. Here, we use an evolutionary model for viruses in the presence of immune host systems with finite memory to obtain a phase diagram of evolutionary patterns in a two-dimensional antigenic space. We find that, for small effective mutation rates and mutation jump ranges, a single lineage is the only stable solution. Large effective mutation rates combined with large mutational jumps in antigenic space lead to multiple stably co-existing lineages over prolonged evolutionary periods. These results combined with observations from data constrain the parameter regimes for the adaptation of viruses, including influenza. MDPI 2019-07-29 /pmc/articles/PMC6789611/ /pubmed/31362404 http://dx.doi.org/10.3390/pathogens8030115 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marchi, Jacopo
Lässig, Michael
Mora, Thierry
Walczak, Aleksandra M.
Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
title Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
title_full Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
title_fullStr Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
title_full_unstemmed Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
title_short Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
title_sort multi-lineage evolution in viral populations driven by host immune systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789611/
https://www.ncbi.nlm.nih.gov/pubmed/31362404
http://dx.doi.org/10.3390/pathogens8030115
work_keys_str_mv AT marchijacopo multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems
AT lassigmichael multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems
AT morathierry multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems
AT walczakaleksandram multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems