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Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789611/ https://www.ncbi.nlm.nih.gov/pubmed/31362404 http://dx.doi.org/10.3390/pathogens8030115 |
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author | Marchi, Jacopo Lässig, Michael Mora, Thierry Walczak, Aleksandra M. |
author_facet | Marchi, Jacopo Lässig, Michael Mora, Thierry Walczak, Aleksandra M. |
author_sort | Marchi, Jacopo |
collection | PubMed |
description | Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of influenza A and the prolonged coexistence of lineages in influenza B. Here, we use an evolutionary model for viruses in the presence of immune host systems with finite memory to obtain a phase diagram of evolutionary patterns in a two-dimensional antigenic space. We find that, for small effective mutation rates and mutation jump ranges, a single lineage is the only stable solution. Large effective mutation rates combined with large mutational jumps in antigenic space lead to multiple stably co-existing lineages over prolonged evolutionary periods. These results combined with observations from data constrain the parameter regimes for the adaptation of viruses, including influenza. |
format | Online Article Text |
id | pubmed-6789611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67896112019-10-16 Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems Marchi, Jacopo Lässig, Michael Mora, Thierry Walczak, Aleksandra M. Pathogens Article Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of influenza A and the prolonged coexistence of lineages in influenza B. Here, we use an evolutionary model for viruses in the presence of immune host systems with finite memory to obtain a phase diagram of evolutionary patterns in a two-dimensional antigenic space. We find that, for small effective mutation rates and mutation jump ranges, a single lineage is the only stable solution. Large effective mutation rates combined with large mutational jumps in antigenic space lead to multiple stably co-existing lineages over prolonged evolutionary periods. These results combined with observations from data constrain the parameter regimes for the adaptation of viruses, including influenza. MDPI 2019-07-29 /pmc/articles/PMC6789611/ /pubmed/31362404 http://dx.doi.org/10.3390/pathogens8030115 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Marchi, Jacopo Lässig, Michael Mora, Thierry Walczak, Aleksandra M. Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
title | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
title_full | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
title_fullStr | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
title_full_unstemmed | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
title_short | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
title_sort | multi-lineage evolution in viral populations driven by host immune systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789611/ https://www.ncbi.nlm.nih.gov/pubmed/31362404 http://dx.doi.org/10.3390/pathogens8030115 |
work_keys_str_mv | AT marchijacopo multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems AT lassigmichael multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems AT morathierry multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems AT walczakaleksandram multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems |