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Impact of HIV-1 Diversity on Its Sensitivity to Neutralization

The HIV-1 pandemic remains a major burden on global public health and a vaccine to prevent HIV-1 infection is highly desirable but has not yet been developed. Among the many roadblocks to achieve this goal, the high antigenic diversity of the HIV-1 envelope protein (Env) is one of the most important...

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Autores principales: Stefic, Karl, Bouvin-Pley, Mélanie, Braibant, Martine, Barin, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789624/
https://www.ncbi.nlm.nih.gov/pubmed/31349655
http://dx.doi.org/10.3390/vaccines7030074
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author Stefic, Karl
Bouvin-Pley, Mélanie
Braibant, Martine
Barin, Francis
author_facet Stefic, Karl
Bouvin-Pley, Mélanie
Braibant, Martine
Barin, Francis
author_sort Stefic, Karl
collection PubMed
description The HIV-1 pandemic remains a major burden on global public health and a vaccine to prevent HIV-1 infection is highly desirable but has not yet been developed. Among the many roadblocks to achieve this goal, the high antigenic diversity of the HIV-1 envelope protein (Env) is one of the most important and challenging to overcome. The recent development of broadly neutralizing antibodies has considerably improved our knowledge on Env structure and its interplay with neutralizing antibodies. This review aims at highlighting how the genetic diversity of HIV-1 thwarts current, and possibly future, vaccine developments. We will focus on the impact of HIV-1 Env diversification on the sensitivity to neutralizing antibodies and the repercussions of this continuous process at a population level.
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spelling pubmed-67896242019-10-16 Impact of HIV-1 Diversity on Its Sensitivity to Neutralization Stefic, Karl Bouvin-Pley, Mélanie Braibant, Martine Barin, Francis Vaccines (Basel) Review The HIV-1 pandemic remains a major burden on global public health and a vaccine to prevent HIV-1 infection is highly desirable but has not yet been developed. Among the many roadblocks to achieve this goal, the high antigenic diversity of the HIV-1 envelope protein (Env) is one of the most important and challenging to overcome. The recent development of broadly neutralizing antibodies has considerably improved our knowledge on Env structure and its interplay with neutralizing antibodies. This review aims at highlighting how the genetic diversity of HIV-1 thwarts current, and possibly future, vaccine developments. We will focus on the impact of HIV-1 Env diversification on the sensitivity to neutralizing antibodies and the repercussions of this continuous process at a population level. MDPI 2019-07-25 /pmc/articles/PMC6789624/ /pubmed/31349655 http://dx.doi.org/10.3390/vaccines7030074 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stefic, Karl
Bouvin-Pley, Mélanie
Braibant, Martine
Barin, Francis
Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
title Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
title_full Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
title_fullStr Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
title_full_unstemmed Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
title_short Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
title_sort impact of hiv-1 diversity on its sensitivity to neutralization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789624/
https://www.ncbi.nlm.nih.gov/pubmed/31349655
http://dx.doi.org/10.3390/vaccines7030074
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