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Cervical Cancer Prevention in Racially Disparate Rural Populations

Background: Undergoing a timely Pap smear, high-risk human papilloma virus (HPV)- and colposcopy-based testing can reduce HPV-associated cervical cancer (CC) development in women. However, in rural areas, women and minorities without insurance do not undergo periodic assessment and remain at greater...

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Autores principales: Olusola, Patti, Ousley, Kia, Ndetan, Harrison, Singh, Karan P., Banerjee, Hirendra Nath, Dasgupta, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789706/
https://www.ncbi.nlm.nih.gov/pubmed/31487904
http://dx.doi.org/10.3390/medicines6030093
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author Olusola, Patti
Ousley, Kia
Ndetan, Harrison
Singh, Karan P.
Banerjee, Hirendra Nath
Dasgupta, Santanu
author_facet Olusola, Patti
Ousley, Kia
Ndetan, Harrison
Singh, Karan P.
Banerjee, Hirendra Nath
Dasgupta, Santanu
author_sort Olusola, Patti
collection PubMed
description Background: Undergoing a timely Pap smear, high-risk human papilloma virus (HPV)- and colposcopy-based testing can reduce HPV-associated cervical cancer (CC) development in women. However, in rural areas, women and minorities without insurance do not undergo periodic assessment and remain at greater risk of HPV infection and CC. Methods: In this study, 173 women from rural East Texas with various ethnic backgrounds were examined thorough HPV/Pap-based testing and colposcopic assessment. Results: Of the 113 informative cases, 77% (87/113) were positive for high-risk HPV infection and 23% of subjects (26/113) were negative. Associations between HPV positivity with young age (p = 0.002), and a low number of pregnancy (p = 0.004) and births (p = 0.005) were evident. Women with long-term use of contraceptives (OR 1.93, 95% CI, 0.80–4.69) were associated with increased risk of HPV infection. African-American women had a higher risk of abnormal Pap outcome compared to Caucasians (OR 5.31, 95% CI, 0.67–42.0). HPV seemed to be a predictor of abnormal Pap outcome (OR 1.77, 95% CI, 0.48–6.44) in these subjects. Unmarried/widowed/divorced women had an increased abnormal Pap test outcome compared to married women or women living with a partner (p = 0.01), with over 278% increased odds (OR 3.78 at 95% CI, 1.29–11.10). Insured women undergoing periodic checkups were detected early with high-risk HPV infection and abnormal Pap test/colposcopic outcome. Conclusions: Comprehensive and timely screening of uninsured women and minorities in rural East Texas are warranted, which could potentially prevent the onset of HPV-associated CC.
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spelling pubmed-67897062019-10-16 Cervical Cancer Prevention in Racially Disparate Rural Populations Olusola, Patti Ousley, Kia Ndetan, Harrison Singh, Karan P. Banerjee, Hirendra Nath Dasgupta, Santanu Medicines (Basel) Article Background: Undergoing a timely Pap smear, high-risk human papilloma virus (HPV)- and colposcopy-based testing can reduce HPV-associated cervical cancer (CC) development in women. However, in rural areas, women and minorities without insurance do not undergo periodic assessment and remain at greater risk of HPV infection and CC. Methods: In this study, 173 women from rural East Texas with various ethnic backgrounds were examined thorough HPV/Pap-based testing and colposcopic assessment. Results: Of the 113 informative cases, 77% (87/113) were positive for high-risk HPV infection and 23% of subjects (26/113) were negative. Associations between HPV positivity with young age (p = 0.002), and a low number of pregnancy (p = 0.004) and births (p = 0.005) were evident. Women with long-term use of contraceptives (OR 1.93, 95% CI, 0.80–4.69) were associated with increased risk of HPV infection. African-American women had a higher risk of abnormal Pap outcome compared to Caucasians (OR 5.31, 95% CI, 0.67–42.0). HPV seemed to be a predictor of abnormal Pap outcome (OR 1.77, 95% CI, 0.48–6.44) in these subjects. Unmarried/widowed/divorced women had an increased abnormal Pap test outcome compared to married women or women living with a partner (p = 0.01), with over 278% increased odds (OR 3.78 at 95% CI, 1.29–11.10). Insured women undergoing periodic checkups were detected early with high-risk HPV infection and abnormal Pap test/colposcopic outcome. Conclusions: Comprehensive and timely screening of uninsured women and minorities in rural East Texas are warranted, which could potentially prevent the onset of HPV-associated CC. MDPI 2019-09-04 /pmc/articles/PMC6789706/ /pubmed/31487904 http://dx.doi.org/10.3390/medicines6030093 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Olusola, Patti
Ousley, Kia
Ndetan, Harrison
Singh, Karan P.
Banerjee, Hirendra Nath
Dasgupta, Santanu
Cervical Cancer Prevention in Racially Disparate Rural Populations
title Cervical Cancer Prevention in Racially Disparate Rural Populations
title_full Cervical Cancer Prevention in Racially Disparate Rural Populations
title_fullStr Cervical Cancer Prevention in Racially Disparate Rural Populations
title_full_unstemmed Cervical Cancer Prevention in Racially Disparate Rural Populations
title_short Cervical Cancer Prevention in Racially Disparate Rural Populations
title_sort cervical cancer prevention in racially disparate rural populations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789706/
https://www.ncbi.nlm.nih.gov/pubmed/31487904
http://dx.doi.org/10.3390/medicines6030093
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