Evaluating the Potential of Younger Cases and Older Controls Cohorts to Improve Discovery Power in Genome-Wide Association Studies of Late-Onset Diseases

For more than a decade, genome-wide association studies have been making steady progress in discovering the causal gene variants that contribute to late-onset human diseases. Polygenic late-onset diseases in an aging population display a risk allele frequency decrease at older ages, caused by indivi...

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Detalles Bibliográficos
Autor principal: Oliynyk, Roman Teo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789773/
https://www.ncbi.nlm.nih.gov/pubmed/31336617
http://dx.doi.org/10.3390/jpm9030038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789773/
https://www.ncbi.nlm.nih.gov/pubmed/31336617
http://dx.doi.org/10.3390/jpm9030038

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