Cargando…

Safety Pharmacological Evaluation of the Coffee Component, Caffeoylquinic Acid, and Its Metabolites, Using Ex Vivo and In Vitro Profiling Assays

Although coffee components have gained interest for use as pharmaceuticals, little is known about their safety pharmacological effects. Hence, we aimed to evaluate the safety pharmacological effects of a chlorogenic acid (CGA)-related compound contained in coffee, 5-O-caffeoylquinic acid (5-CQA), an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amano, Yuto, Honda, Hiroshi, Nukada, Yuko, Ikeda, Naohiro, Yamane, Masayuki, Nakano, Koji, Kameyama, Akiyo, Morita, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789782/ https://www.ncbi.nlm.nih.gov/pubmed/31319524 http://dx.doi.org/10.3390/ph12030110

Ejemplares similares

4″-Sulfation Is the Major Metabolic Pathway of Epigallocatechin-3-gallate in Humans: Characterization of Metabolites, Enzymatic Analysis, and Pharmacokinetic Profiling
por: Hayashi, Akane, et al.
Publicado: (2022)

Quantification of Caffeoylquinic Acids in Coffee Brews by HPLC-DAD
por: Moeenfard, Marzieh, et al.
Publicado: (2014)

RAID: Regression Analysis–Based Inductive DNA Microarray for Precise Read-Across
por: Amano, Yuto, et al.
Publicado: (2022)

Comparative environmental RNA and DNA metabarcoding analysis of river algae and arthropods for ecological surveys and water quality assessment
por: Miyata, Kaede, et al.
Publicado: (2022)

Bioinspired 5-caffeoylquinic acid capped silver nanoparticles using Coffee arabica leaf extract for high-sensitive cysteine detection
por: Harsha Haridas, E. S., et al.
Publicado: (2023)

Caffeoylquinic Acid Enhances Proliferation of Oligodendrocyte Precursor Cells
por: Yanqin, Ying, et al.
Publicado: (2017)

Caffeoylquinic Acids Generated In Vitro in a High-Anthocyanin-Accumulating Sweet Potato Cell Line
por: Konczak, Izabela, et al.
Publicado: (2004)

Chemical-Induced Cleft Palate Is Caused and Rescued by Pharmacological Modulation of the Canonical Wnt Signaling Pathway in a Zebrafish Model
por: Narumi, Rika, et al.
Publicado: (2020)

A genome-wide mutation analysis method enabling high-throughput identification of chemical mutagen signatures
por: Matsumura, Shoji, et al.
Publicado: (2018)

Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content
por: Wong, Siu Kuin, et al.
Publicado: (2014)

Caffeoylquinic Acids from the Aerial Parts of Chrysanthemum coronarium L.
por: Wan, Chunpeng, et al.
Publicado: (2017)

Sprout Caffeoylquinic Acid Profiles as Affected by Variety, Cooking, and Storage
por: Khaksar, Gholamreza, et al.
Publicado: (2021)

Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica
por: Yu, Yang, et al.
Publicado: (2015)

Synthesis and In Vitro Evaluation of Caffeoylquinic Acid Derivatives as Potential Hypolipidemic Agents
por: Tian, Yu, et al.
Publicado: (2019)

Characterization of Caffeoylquinic Acids from Lepisorus thunbergianus and Their Melanogenesis Inhibitory Activity
por: Kim, Hak Hyun, et al.
Publicado: (2020)

Validation of AIST‐SHANEL Model Based on Spatiotemporally Extensive Monitoring Data of Linear Alkylbenzene Sulfonate in Japan: Toward a Better Strategy on Deriving Predicted Environmental Concentrations
por: Nishioka, Tohru, et al.
Publicado: (2019)

Genotoxicity evaluation of alpha-linolenic acid-diacylglycerol oil
por: Honda, Hiroshi, et al.
Publicado: (2016)

Neuroprotective effects of 3,5-di-o-caffeoylquinic acid in vitro and in vivo
por: Han, Junkyu, et al.
Publicado: (2011)

Single-strand specific nuclease enhances accuracy of error-corrected sequencing and improves rare mutation-detection sensitivity
por: Otsubo, Yuki, et al.
Publicado: (2021)

New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of Chrysanthemum morifolium and Their Bioactivities
por: Yang, Peng-Fei, et al.
Publicado: (2019)

Improvement in the Cynaropicrin, Caffeoylquinic Acid and Flavonoid Content of Globe Artichokes with Gibberellic Acid Treatment
por: Lombardo, Sara, et al.
Publicado: (2022)

Effects of drying on caffeoylquinic acid derivative content and antioxidant capacity of sweet potato leaves
por: Jeng, Toong Long, et al.
Publicado: (2014)

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds
por: Ganzon, Jerome G., et al.
Publicado: (2017)

Induction of AhR-Mediated Gene Transcription by Coffee
por: Ishikawa, Toshio, et al.
Publicado: (2014)

NMR Studies of Hetero-Association of Caffeine with di-O-Caffeoylquinic Acid Isomers in Aqueous Solution
por: D’Amelio, Nicola, et al.
Publicado: (2014)

Identification and Functional Characterization of Genes Involved in the Biosynthesis of Caffeoylquinic Acids in Sunflower (Helianthus annuus L.)
por: Cheevarungnapakul, Ketthida, et al.
Publicado: (2019)

Bakkenolides and Caffeoylquinic Acids from the Aerial Portion of Petasites japonicus and Their Bacterial Neuraminidase Inhibition Ability
por: Woo, Hyun Sim, et al.
Publicado: (2020)

Caffeoylquinic Acid Derivatives of Purple Sweet Potato as Modulators of Mitochondrial Function in Mouse Primary Hepatocytes
por: Torres, Andrea, et al.
Publicado: (2021)

Callus Culture of Scorzonera radiata as a New, Highly Productive and Stable Source of Caffeoylquinic Acids
por: Grishchenko, Olga V., et al.
Publicado: (2022)

Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders
por: Liu, Yameng, et al.
Publicado: (2022)

Effect of Chlorogenic Acid (5-Caffeoylquinic Acid) Isolated from Baccharis oxyodonta on the Structure and Pharmacological Activities of Secretory Phospholipase A2 from Crotalus durissus terrificus
por: Toyama, Daniela O., et al.
Publicado: (2014)

Hawk-Seq™ differentiates between various mutations in Salmonella typhimurium TA100 strain caused by exposure to Ames test-positive mutagens
por: Otsubo, Yuki, et al.
Publicado: (2021)

Campylobacter jejuni Bacteremia in the Term Infant A Rare Cause of Neonatal Hematochezia
por: Mizuno, Shinsuke, et al.
Publicado: (2022)

Urinary Excretion of Niacin Metabolites in Humans After Coffee Consumption
por: Kremer, Jonathan Isaak, et al.
Publicado: (2018)

Metabolite Profiles of the Green Beans of Indonesian Arabica Coffee Varieties
por: Happyana, Nizar, et al.
Publicado: (2021)

Caffeoylquinic Acids Are Major Constituents with Potent Anti-Influenza Effects in Brazilian Green Propolis Water Extract
por: Urushisaki, Tomohiko, et al.
Publicado: (2011)

In Vivo and In Vitro Anti-Arthritic Effects of Cardenolide-Rich and Caffeoylquinic Acid-Rich Fractions of Periploca forrestii
por: Liu, Ting, et al.
Publicado: (2018)

Use of [C(4)mim]Cl for efficient extraction of caffeoylquinic acids from sweet potato leaves
por: Usuki, Toyonobu, et al.
Publicado: (2017)

Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation
por: Zhang, Xi, et al.
Publicado: (2021)

Determination of Caffeoylquinic Acids Content by UHPLC in Scolymus hispanicus Extracts Obtained through Ultrasound-Assisted Extraction
por: Ruano-González, Antonio, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u0lm1fsq04nvg4h7oe2e4ml49b