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Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs

Dogs that are infected with Babesia canis parasites usually show severe clinical signs, yet often very few parasites are detectable in the blood circulation. The results showed that large numbers of B. canis-infected red blood cells accumulate in the microvasculature of infected subjects. The initia...

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Autor principal: Schetters, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789894/
https://www.ncbi.nlm.nih.gov/pubmed/31261942
http://dx.doi.org/10.3390/pathogens8030094
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author Schetters, Theo
author_facet Schetters, Theo
author_sort Schetters, Theo
collection PubMed
description Dogs that are infected with Babesia canis parasites usually show severe clinical signs, yet often very few parasites are detectable in the blood circulation. The results showed that large numbers of B. canis-infected red blood cells accumulate in the microvasculature of infected subjects. The initial process leading to the attachment of infected erythrocytes to the endothelial cells of small capillaries (sequestration) appears to involve the interaction of parasite molecules at the erythrocyte surface with ligands on the endothelial cells. Since parasites continue to develop in the sequestered erythrocyte, it would be expected that the infected erythrocyte is destroyed when the mature parasites escape the host cell, which would make it hard to explain accumulation of infected erythrocytes at the initial site of attachment. Apparently, additional processes are triggered that lead to consolidation of parasite sequestration. One possible explanation is that after initial attachment of an infected erythrocyte to the wall of a blood capillary, the coagulation system is involved in the trapping of infected and uninfected erythrocytes. The data further suggest that newly formed parasites subsequently infect normal red blood cells that are also trapped in the capillary, which finally leads to capillaries that appear to be loaded with infected erythrocytes.
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spelling pubmed-67898942019-10-16 Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs Schetters, Theo Pathogens Review Dogs that are infected with Babesia canis parasites usually show severe clinical signs, yet often very few parasites are detectable in the blood circulation. The results showed that large numbers of B. canis-infected red blood cells accumulate in the microvasculature of infected subjects. The initial process leading to the attachment of infected erythrocytes to the endothelial cells of small capillaries (sequestration) appears to involve the interaction of parasite molecules at the erythrocyte surface with ligands on the endothelial cells. Since parasites continue to develop in the sequestered erythrocyte, it would be expected that the infected erythrocyte is destroyed when the mature parasites escape the host cell, which would make it hard to explain accumulation of infected erythrocytes at the initial site of attachment. Apparently, additional processes are triggered that lead to consolidation of parasite sequestration. One possible explanation is that after initial attachment of an infected erythrocyte to the wall of a blood capillary, the coagulation system is involved in the trapping of infected and uninfected erythrocytes. The data further suggest that newly formed parasites subsequently infect normal red blood cells that are also trapped in the capillary, which finally leads to capillaries that appear to be loaded with infected erythrocytes. MDPI 2019-06-29 /pmc/articles/PMC6789894/ /pubmed/31261942 http://dx.doi.org/10.3390/pathogens8030094 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schetters, Theo
Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs
title Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs
title_full Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs
title_fullStr Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs
title_full_unstemmed Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs
title_short Mechanisms Involved in the Persistence of Babesia canis Infection in Dogs
title_sort mechanisms involved in the persistence of babesia canis infection in dogs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789894/
https://www.ncbi.nlm.nih.gov/pubmed/31261942
http://dx.doi.org/10.3390/pathogens8030094
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