Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

Mutations in the iPLA2-VIA/PLA2G6 gene are responsible for PARK14-linked Parkinson’s disease (PD) with α-synucleinopathy. However, it is unclear how iPLA2-VIA mutations lead to α-synuclein (α-Syn) aggregation and dopaminergic (DA) neurodegeneration. Here, we report that iPLA2-VIA–deficient Drosophil...

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Detalles Bibliográficos
Autores principales: Mori, Akio, Hatano, Taku, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Koinuma, Takahiro, Meng, Hongrui, Kubo, Shin-ichiro, Spratt, Spencer, Cui, Changxu, Yamashita, Chikara, Miki, Yoshimi, Yamamoto, Kei, Hirabayashi, Tetsuya, Murakami, Makoto, Takahashi, Yoshikazu, Shindou, Hideo, Nonaka, Takashi, Hasegawa, Masato, Okuzumi, Ayami, Imai, Yuzuru, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789907/
https://www.ncbi.nlm.nih.gov/pubmed/31548400
http://dx.doi.org/10.1073/pnas.1902958116

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