Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

BACKGROUND: The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (6.p22) in CN-AML patient blasts. Here, we further investigate the molecular,...

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Detalles Bibliográficos
Autores principales: Garciaz, Sylvain, N’guyen Dasi, Lia, Finetti, Pascal, Chevalier, Christine, Vernerey, Julien, Poplineau, Mathilde, Platet, Nadine, Audebert, Stéphane, Pophillat, Matthieu, Camoin, Luc, Bertucci, François, Calmels, Boris, Récher, Christian, Birnbaum, Daniel, Chabannon, Christian, Vey, Norbert, Duprez, Estelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790061/
https://www.ncbi.nlm.nih.gov/pubmed/31606046
http://dx.doi.org/10.1186/s13148-019-0738-6

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