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How does the immune system learn to distinguish between good and evil? The first definitive studies of T cell central tolerance and positive selection
Demonstration that immature CD4 + 8+ thymocytes contain T cell precursors that are subjected to positive and negative selection was the major step towards understanding how the adaptive immune system acquires the ability to distinguish foreign or abnormal (mutated or infected) self-cells from normal...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790186/ https://www.ncbi.nlm.nih.gov/pubmed/31418051 http://dx.doi.org/10.1007/s00251-019-01127-8 |