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High levels of plasma fibrinogen are related to post‐stroke cognitive impairment

INTRODUCTION: Studies have shown that high levels of the fibrinogen (FIB) are related to cognitive deficits. However, the relationship between fibrinogen and cognitive deficit after stroke remains unclear. Therefore, we explored the relationship between plasma fibrinogen and post‐stroke cognitive im...

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Autores principales: Liu, Yuntao, Chen, Huijun, Zhao, Kai, He, Weilei, Lin, Shasha, He, Jincai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790326/
https://www.ncbi.nlm.nih.gov/pubmed/31475471
http://dx.doi.org/10.1002/brb3.1391
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author Liu, Yuntao
Chen, Huijun
Zhao, Kai
He, Weilei
Lin, Shasha
He, Jincai
author_facet Liu, Yuntao
Chen, Huijun
Zhao, Kai
He, Weilei
Lin, Shasha
He, Jincai
author_sort Liu, Yuntao
collection PubMed
description INTRODUCTION: Studies have shown that high levels of the fibrinogen (FIB) are related to cognitive deficits. However, the relationship between fibrinogen and cognitive deficit after stroke remains unclear. Therefore, we explored the relationship between plasma fibrinogen and post‐stroke cognitive impairment (PSCI). METHODS: This study is carried out in the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China. A total of 210 patients with acute ischemic stroke were enrolled in this study. Ultimately, 134 patients completed 3‐month follow‐up. Blood samples were collected at hospital admission. Cognitive function was evaluated 3 months after stroke. All patients underwent the Mini‐Mental State Examination (MMSE) after 3 months. RESULTS: Higher levels of fibrinogen were observed in patients with post‐stroke cognitive impairment compared with the non‐PSCI group (p < .001). Additionally, elevated plasma fibrinogen levels were independently associated with PSCI (odds ratio [OR] = 2.000, 95% CI 1.062–3.770 p = .032). The plasma fibrinogen levels were negatively correlated with the 3‐month MMSE scores (r = −.171, p = .048). In a multivariate linear regression, FIB was negatively associated with the 3‐month MMSE scores after adjustment for the other variables (β = −0.782, p = .035). CONCLUSION: High levels of plasma fibrinogen were associated with the presence and severity of PSCI.
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spelling pubmed-67903262019-10-21 High levels of plasma fibrinogen are related to post‐stroke cognitive impairment Liu, Yuntao Chen, Huijun Zhao, Kai He, Weilei Lin, Shasha He, Jincai Brain Behav Original Research INTRODUCTION: Studies have shown that high levels of the fibrinogen (FIB) are related to cognitive deficits. However, the relationship between fibrinogen and cognitive deficit after stroke remains unclear. Therefore, we explored the relationship between plasma fibrinogen and post‐stroke cognitive impairment (PSCI). METHODS: This study is carried out in the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China. A total of 210 patients with acute ischemic stroke were enrolled in this study. Ultimately, 134 patients completed 3‐month follow‐up. Blood samples were collected at hospital admission. Cognitive function was evaluated 3 months after stroke. All patients underwent the Mini‐Mental State Examination (MMSE) after 3 months. RESULTS: Higher levels of fibrinogen were observed in patients with post‐stroke cognitive impairment compared with the non‐PSCI group (p < .001). Additionally, elevated plasma fibrinogen levels were independently associated with PSCI (odds ratio [OR] = 2.000, 95% CI 1.062–3.770 p = .032). The plasma fibrinogen levels were negatively correlated with the 3‐month MMSE scores (r = −.171, p = .048). In a multivariate linear regression, FIB was negatively associated with the 3‐month MMSE scores after adjustment for the other variables (β = −0.782, p = .035). CONCLUSION: High levels of plasma fibrinogen were associated with the presence and severity of PSCI. John Wiley and Sons Inc. 2019-09-02 /pmc/articles/PMC6790326/ /pubmed/31475471 http://dx.doi.org/10.1002/brb3.1391 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Liu, Yuntao
Chen, Huijun
Zhao, Kai
He, Weilei
Lin, Shasha
He, Jincai
High levels of plasma fibrinogen are related to post‐stroke cognitive impairment
title High levels of plasma fibrinogen are related to post‐stroke cognitive impairment
title_full High levels of plasma fibrinogen are related to post‐stroke cognitive impairment
title_fullStr High levels of plasma fibrinogen are related to post‐stroke cognitive impairment
title_full_unstemmed High levels of plasma fibrinogen are related to post‐stroke cognitive impairment
title_short High levels of plasma fibrinogen are related to post‐stroke cognitive impairment
title_sort high levels of plasma fibrinogen are related to post‐stroke cognitive impairment
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790326/
https://www.ncbi.nlm.nih.gov/pubmed/31475471
http://dx.doi.org/10.1002/brb3.1391
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