Clozapine As Transformative Treatment In Bipolar Patients

Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness i...

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Detalles Bibliográficos
Autores principales: Wilkowska, Alina, Cubała, Wiesław J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790347/
https://www.ncbi.nlm.nih.gov/pubmed/31632038
http://dx.doi.org/10.2147/NDT.S227196
Descripción
Sumario:Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.

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