Clozapine As Transformative Treatment In Bipolar Patients

Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness i...

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Autores principales: Wilkowska, Alina, Cubała, Wiesław J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790347/
https://www.ncbi.nlm.nih.gov/pubmed/31632038
http://dx.doi.org/10.2147/NDT.S227196
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author Wilkowska, Alina
Cubała, Wiesław J
author_facet Wilkowska, Alina
Cubała, Wiesław J
author_sort Wilkowska, Alina
collection PubMed
description Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.
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spelling pubmed-67903472019-10-18 Clozapine As Transformative Treatment In Bipolar Patients Wilkowska, Alina Cubała, Wiesław J Neuropsychiatr Dis Treat Hypothesis Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease. Dove 2019-10-09 /pmc/articles/PMC6790347/ /pubmed/31632038 http://dx.doi.org/10.2147/NDT.S227196 Text en © 2019 Wilkowska and Cubała. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Hypothesis
Wilkowska, Alina
Cubała, Wiesław J
Clozapine As Transformative Treatment In Bipolar Patients
title Clozapine As Transformative Treatment In Bipolar Patients
title_full Clozapine As Transformative Treatment In Bipolar Patients
title_fullStr Clozapine As Transformative Treatment In Bipolar Patients
title_full_unstemmed Clozapine As Transformative Treatment In Bipolar Patients
title_short Clozapine As Transformative Treatment In Bipolar Patients
title_sort clozapine as transformative treatment in bipolar patients
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790347/
https://www.ncbi.nlm.nih.gov/pubmed/31632038
http://dx.doi.org/10.2147/NDT.S227196
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