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Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia

The Saudi Particle Therapy Centre (SPTC) is establishing proton beam therapy (PBT) services within Kingdom of Saudi Arabia (KSA). Thus, national guidelines for the pertinent draft, and recommendations of PBT for cancer patients are utmost important. Saudi Particle Therapy Centre invited a panel of e...

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Autores principales: AlHussain, Hussain, Balbaid, Ali, Malyapa, Robert, AlOthman, Majid, Bahadur, Yasser A., Tunio, Mutahir A., Al Asiri, Mushabbab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790482/
https://www.ncbi.nlm.nih.gov/pubmed/31522214
http://dx.doi.org/10.15537/smj.2019.9.24496
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author AlHussain, Hussain
Balbaid, Ali
Malyapa, Robert
AlOthman, Majid
Bahadur, Yasser A.
Tunio, Mutahir A.
Al Asiri, Mushabbab
author_facet AlHussain, Hussain
Balbaid, Ali
Malyapa, Robert
AlOthman, Majid
Bahadur, Yasser A.
Tunio, Mutahir A.
Al Asiri, Mushabbab
author_sort AlHussain, Hussain
collection PubMed
description The Saudi Particle Therapy Centre (SPTC) is establishing proton beam therapy (PBT) services within Kingdom of Saudi Arabia (KSA). Thus, national guidelines for the pertinent draft, and recommendations of PBT for cancer patients are utmost important. Saudi Particle Therapy Centre invited a panel of expert radiation oncologists practicing within KSA to formulate national clinical practice guidelines for the referral, absolute and relative indications and dose/fractionation for PBT. After identifying the key clinical questions, ample search through PubMed, EMBASE, and various search drives was accomplished for appropriate meta-analyses, clinical trials, case-control, and case series studies, and case reports. Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach was incorporated to formulate various recommendations. Saudi Particle Therapy Centre expert panel recommended PBT as utter modality for ocular tumors, base of skull/spine tumors, hepatocellular carcinoma, all pediatric central nervous system (CNS) malignancies, para-nasal sinuses/nasal cavity tumors and for re-irradiation of all sites aimed for cure. However, PBT may be contemplated, as a relative indication if no other parallel option is available, or when photon therapy plans exceed the dose constraints for critical structures. Further, panel did not recommend routine PBT for other sites beyond clinical trials. However, individual oncology patients can be considered for PBT after a multidisciplinary approach and expert’s opinion.
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spelling pubmed-67904822021-02-26 Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia AlHussain, Hussain Balbaid, Ali Malyapa, Robert AlOthman, Majid Bahadur, Yasser A. Tunio, Mutahir A. Al Asiri, Mushabbab Saudi Med J Clinical Practice Guidelines The Saudi Particle Therapy Centre (SPTC) is establishing proton beam therapy (PBT) services within Kingdom of Saudi Arabia (KSA). Thus, national guidelines for the pertinent draft, and recommendations of PBT for cancer patients are utmost important. Saudi Particle Therapy Centre invited a panel of expert radiation oncologists practicing within KSA to formulate national clinical practice guidelines for the referral, absolute and relative indications and dose/fractionation for PBT. After identifying the key clinical questions, ample search through PubMed, EMBASE, and various search drives was accomplished for appropriate meta-analyses, clinical trials, case-control, and case series studies, and case reports. Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach was incorporated to formulate various recommendations. Saudi Particle Therapy Centre expert panel recommended PBT as utter modality for ocular tumors, base of skull/spine tumors, hepatocellular carcinoma, all pediatric central nervous system (CNS) malignancies, para-nasal sinuses/nasal cavity tumors and for re-irradiation of all sites aimed for cure. However, PBT may be contemplated, as a relative indication if no other parallel option is available, or when photon therapy plans exceed the dose constraints for critical structures. Further, panel did not recommend routine PBT for other sites beyond clinical trials. However, individual oncology patients can be considered for PBT after a multidisciplinary approach and expert’s opinion. Saudi Medical Journal 2019-09 /pmc/articles/PMC6790482/ /pubmed/31522214 http://dx.doi.org/10.15537/smj.2019.9.24496 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Practice Guidelines
AlHussain, Hussain
Balbaid, Ali
Malyapa, Robert
AlOthman, Majid
Bahadur, Yasser A.
Tunio, Mutahir A.
Al Asiri, Mushabbab
Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia
title Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia
title_full Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia
title_fullStr Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia
title_full_unstemmed Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia
title_short Defining Clinical Indications of Proton Beam Therapy at National Level in the Kingdom of Saudi Arabia
title_sort defining clinical indications of proton beam therapy at national level in the kingdom of saudi arabia
topic Clinical Practice Guidelines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790482/
https://www.ncbi.nlm.nih.gov/pubmed/31522214
http://dx.doi.org/10.15537/smj.2019.9.24496
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