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N‐Linked Glycans in the Variable Domain of IgG Anti–Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis

OBJECTIVE: Anti–citrullinated protein antibodies (ACPAs) are disease‐specific biomarkers in rheumatoid arthritis (RA). More than 90% of IgG ACPAs harbor N‐linked glycans in the antibody variable (V) domain. The corresponding N‐glycosylation sites in ACPA V‐region sequences result from somatic hyperm...

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Detalles Bibliográficos
Autores principales:	Hafkenscheid, Lise, de Moel, Emma, Smolik, Irene, Tanner, Stacey, Meng, Xiaobo, Jansen, Bas C., Bondt, Albert, Wuhrer, Manfred, Huizinga, Tom W. J., Toes, Rene E. M., El‐Gabalawy, Hani, Scherer, Hans U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Rheumatoid Arthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790576/ https://www.ncbi.nlm.nih.gov/pubmed/31067000 http://dx.doi.org/10.1002/art.40920

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