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Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

SCOPE: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. METHODS AND RESULTS: A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years and initially free of dementia. A total of 209 cases of cog...

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Autores principales: Low, Dorrain Yanwen, Lefèvre‐Arbogast, Sophie, González‐Domínguez, Raúl, Urpi‐Sarda, Mireia, Micheau, Pierre, Petera, Melanie, Centeno, Delphine, Durand, Stephanie, Pujos‐Guillot, Estelle, Korosi, Aniko, Lucassen, Paul J, Aigner, Ludwig, Proust‐Lima, Cécile, Hejblum, Boris P, Helmer, Catherine, Andres‐Lacueva, Cristina, Thuret, Sandrine, Samieri, Cécilia, Manach, Claudine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790579/
https://www.ncbi.nlm.nih.gov/pubmed/31218777
http://dx.doi.org/10.1002/mnfr.201900177
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author Low, Dorrain Yanwen
Lefèvre‐Arbogast, Sophie
González‐Domínguez, Raúl
Urpi‐Sarda, Mireia
Micheau, Pierre
Petera, Melanie
Centeno, Delphine
Durand, Stephanie
Pujos‐Guillot, Estelle
Korosi, Aniko
Lucassen, Paul J
Aigner, Ludwig
Proust‐Lima, Cécile
Hejblum, Boris P
Helmer, Catherine
Andres‐Lacueva, Cristina
Thuret, Sandrine
Samieri, Cécilia
Manach, Claudine
author_facet Low, Dorrain Yanwen
Lefèvre‐Arbogast, Sophie
González‐Domínguez, Raúl
Urpi‐Sarda, Mireia
Micheau, Pierre
Petera, Melanie
Centeno, Delphine
Durand, Stephanie
Pujos‐Guillot, Estelle
Korosi, Aniko
Lucassen, Paul J
Aigner, Ludwig
Proust‐Lima, Cécile
Hejblum, Boris P
Helmer, Catherine
Andres‐Lacueva, Cristina
Thuret, Sandrine
Samieri, Cécilia
Manach, Claudine
author_sort Low, Dorrain Yanwen
collection PubMed
description SCOPE: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. METHODS AND RESULTS: A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gender, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap‐enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium‐chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE‐ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross‐validated Area Under the Receiver Operating Curve = 75% [95% CI 70–80%] compared to 62% [95% CI 56–67%]. CONCLUSIONS: The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging.
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spelling pubmed-67905792019-10-18 Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort Low, Dorrain Yanwen Lefèvre‐Arbogast, Sophie González‐Domínguez, Raúl Urpi‐Sarda, Mireia Micheau, Pierre Petera, Melanie Centeno, Delphine Durand, Stephanie Pujos‐Guillot, Estelle Korosi, Aniko Lucassen, Paul J Aigner, Ludwig Proust‐Lima, Cécile Hejblum, Boris P Helmer, Catherine Andres‐Lacueva, Cristina Thuret, Sandrine Samieri, Cécilia Manach, Claudine Mol Nutr Food Res Research Articles SCOPE: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. METHODS AND RESULTS: A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gender, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap‐enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium‐chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE‐ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross‐validated Area Under the Receiver Operating Curve = 75% [95% CI 70–80%] compared to 62% [95% CI 56–67%]. CONCLUSIONS: The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging. John Wiley and Sons Inc. 2019-07-09 2019-09 /pmc/articles/PMC6790579/ /pubmed/31218777 http://dx.doi.org/10.1002/mnfr.201900177 Text en © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Low, Dorrain Yanwen
Lefèvre‐Arbogast, Sophie
González‐Domínguez, Raúl
Urpi‐Sarda, Mireia
Micheau, Pierre
Petera, Melanie
Centeno, Delphine
Durand, Stephanie
Pujos‐Guillot, Estelle
Korosi, Aniko
Lucassen, Paul J
Aigner, Ludwig
Proust‐Lima, Cécile
Hejblum, Boris P
Helmer, Catherine
Andres‐Lacueva, Cristina
Thuret, Sandrine
Samieri, Cécilia
Manach, Claudine
Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
title Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
title_full Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
title_fullStr Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
title_full_unstemmed Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
title_short Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
title_sort diet‐related metabolites associated with cognitive decline revealed by untargeted metabolomics in a prospective cohort
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790579/
https://www.ncbi.nlm.nih.gov/pubmed/31218777
http://dx.doi.org/10.1002/mnfr.201900177
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