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SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation

Acute myeloid leukaemia (AML) cells possess metabolism profiles, such as higher rates of oxidative phosphorylation and dependence on fatty acid oxidation for survival, and are dependent on the sophisticated regulation of reactive oxygen species (ROS) generation for survival, drug resistance and stem...

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Detalles Bibliográficos
Autores principales:	Ma, Jiao, Liu, Bin, Yu, Dan, Zuo, Yong, Cai, Rong, Yang, Jianmin, Cheng, Jinke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Haematological Malignancy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790595/ https://www.ncbi.nlm.nih.gov/pubmed/31236919 http://dx.doi.org/10.1111/bjh.16044

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