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Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases

BACKGROUND: Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region‐specific thickness analysis of retinal layers could improve the detection of macular atrophy and unravel its association wit...

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Autores principales: Murueta‐Goyena, Ane, del Pino, Rocío, Reyero, Paula, Galdós, Marta, Arana, Begoña, Lucas‐Jiménez, Olaia, Acera, Marian, Tijero, Beatriz, Ibarretxe‐Bilbao, Naroa, Ojeda, Natalia, Peña, Javier, Cortés, Jesús, Gómez‐Esteban, Juan Carlos, Gabilondo, Iñigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790692/
https://www.ncbi.nlm.nih.gov/pubmed/31136022
http://dx.doi.org/10.1002/mds.27728
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author Murueta‐Goyena, Ane
del Pino, Rocío
Reyero, Paula
Galdós, Marta
Arana, Begoña
Lucas‐Jiménez, Olaia
Acera, Marian
Tijero, Beatriz
Ibarretxe‐Bilbao, Naroa
Ojeda, Natalia
Peña, Javier
Cortés, Jesús
Gómez‐Esteban, Juan Carlos
Gabilondo, Iñigo
author_facet Murueta‐Goyena, Ane
del Pino, Rocío
Reyero, Paula
Galdós, Marta
Arana, Begoña
Lucas‐Jiménez, Olaia
Acera, Marian
Tijero, Beatriz
Ibarretxe‐Bilbao, Naroa
Ojeda, Natalia
Peña, Javier
Cortés, Jesús
Gómez‐Esteban, Juan Carlos
Gabilondo, Iñigo
author_sort Murueta‐Goyena, Ane
collection PubMed
description BACKGROUND: Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region‐specific thickness analysis of retinal layers could improve the detection of macular atrophy and unravel its association with visual disability in Parkinson's disease. METHODS: Patients with idiopathic Parkinson's disease (n = 63), dementia with Lewy bodies (n = 8), and E46K mutation carriers in the α‐synuclein gene (E46K‐SNCA) (n = 4) and 34 controls underwent Spectralis optical coherence tomography macular scans and a comprehensive battery of visual function and cognition tests. We computed mean retinal layer thicknesses of both eyes within 1‐, 2‐, 3‐, and 6‐mm diameter macular discs and in concentric parafoveal (1‐ to 2‐mm, 2‐ to 3‐mm, 1‐ to 3‐mm) and perifoveal (3‐ to 6‐mm) rings. Group differences in imaging parameters and their relationship with visual outcomes were analyzed. A multivariate logistic model was developed to predict visual impairment from optical coherence tomography measurements in Parkinson's disease, and cutoff values were determined with receiver operating characteristic analysis. RESULTS: When compared with controls, patients with dementia with Lewy bodies had significant thinning of the ganglion cell–inner plexiform layer complex within the central 3‐mm disc mainly because of differences in 1‐ to 3‐mm parafoveal thickness. This parameter was strongly correlated in patients, but not in controls, with low contrast visual acuity and visual cognition outcomes (P < .05, False Discovery Rate), achieving 88% of accuracy in predicting visual impairment in Parkinson's disease. CONCLUSION: Our findings support that parafoveal thinning of ganglion cell–inner plexiform complex is a sensitive and clinically relevant imaging biomarker for Lewy body diseases, specifically for Parkinson's disease. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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spelling pubmed-67906922019-10-18 Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases Murueta‐Goyena, Ane del Pino, Rocío Reyero, Paula Galdós, Marta Arana, Begoña Lucas‐Jiménez, Olaia Acera, Marian Tijero, Beatriz Ibarretxe‐Bilbao, Naroa Ojeda, Natalia Peña, Javier Cortés, Jesús Gómez‐Esteban, Juan Carlos Gabilondo, Iñigo Mov Disord Research Articles BACKGROUND: Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region‐specific thickness analysis of retinal layers could improve the detection of macular atrophy and unravel its association with visual disability in Parkinson's disease. METHODS: Patients with idiopathic Parkinson's disease (n = 63), dementia with Lewy bodies (n = 8), and E46K mutation carriers in the α‐synuclein gene (E46K‐SNCA) (n = 4) and 34 controls underwent Spectralis optical coherence tomography macular scans and a comprehensive battery of visual function and cognition tests. We computed mean retinal layer thicknesses of both eyes within 1‐, 2‐, 3‐, and 6‐mm diameter macular discs and in concentric parafoveal (1‐ to 2‐mm, 2‐ to 3‐mm, 1‐ to 3‐mm) and perifoveal (3‐ to 6‐mm) rings. Group differences in imaging parameters and their relationship with visual outcomes were analyzed. A multivariate logistic model was developed to predict visual impairment from optical coherence tomography measurements in Parkinson's disease, and cutoff values were determined with receiver operating characteristic analysis. RESULTS: When compared with controls, patients with dementia with Lewy bodies had significant thinning of the ganglion cell–inner plexiform layer complex within the central 3‐mm disc mainly because of differences in 1‐ to 3‐mm parafoveal thickness. This parameter was strongly correlated in patients, but not in controls, with low contrast visual acuity and visual cognition outcomes (P < .05, False Discovery Rate), achieving 88% of accuracy in predicting visual impairment in Parkinson's disease. CONCLUSION: Our findings support that parafoveal thinning of ganglion cell–inner plexiform complex is a sensitive and clinically relevant imaging biomarker for Lewy body diseases, specifically for Parkinson's disease. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. John Wiley & Sons, Inc. 2019-05-28 2019-09 /pmc/articles/PMC6790692/ /pubmed/31136022 http://dx.doi.org/10.1002/mds.27728 Text en © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Murueta‐Goyena, Ane
del Pino, Rocío
Reyero, Paula
Galdós, Marta
Arana, Begoña
Lucas‐Jiménez, Olaia
Acera, Marian
Tijero, Beatriz
Ibarretxe‐Bilbao, Naroa
Ojeda, Natalia
Peña, Javier
Cortés, Jesús
Gómez‐Esteban, Juan Carlos
Gabilondo, Iñigo
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
title Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
title_full Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
title_fullStr Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
title_full_unstemmed Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
title_short Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
title_sort parafoveal thinning of inner retina is associated with visual dysfunction in lewy body diseases
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790692/
https://www.ncbi.nlm.nih.gov/pubmed/31136022
http://dx.doi.org/10.1002/mds.27728
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